摘要
淫羊藿次苷Ⅱ是淫羊藿苷在体内的药理代谢产物,具有口服吸收快、血浆药物达峰时间短、半衰期较长、多重药理学作用等优势。现代药理研究表明,淫羊藿次苷Ⅱ在抗肿瘤、抗骨质疏松症、改善心血管功能中表现出强大的药理作用,其对中枢神经系统保护作用的机制仍不清楚。本文通过归纳总结淫羊藿次苷Ⅱ在阿尔茨海默病、帕金森病、脑缺血损伤、血管性痴呆等疾病中的作用机制,发现淫羊藿次苷Ⅱ可通过多途径发挥中枢神经保护作用,为中枢神经系统疾病新药开发提供理论依据。
IcarisideⅡis a pharmacological metabolite of icariin in vivo,with advantages such as rapid oral absorption,a short time to reach peak plasma concentration,a relatively long half-life,and multiple pharmacological effects.Modern pharmacological research has shown that icarisideⅡexhibits strong pharmacological effects in anti-tumor,anti-osteoporosis,and improving cardiovascular function,but its mechanism of protective action on the central nervous system remains unclear.This paper summarized the mechanisms of icarisideⅡin Alzheimer's disease,Parkinson's disease,cerebral ischemic injury,and vascular dementia,and found that icarisideⅡcould exert protective effects on central nervous system through multiple pathways,providing a theoretical basis for the development of new drugs for central nervous system diseases.
作者
马正安
顾万红
王雪梅
李喜香
MA Zheng'an;GU Wanhong;WANG Xuemei;LI Xixiang(Gansu Provincial Hospital of Traditional Chinese Medicine,Lanzhou 730050)
出处
《中药药理与临床》
北大核心
2025年第10期108-112,共5页
Pharmacology and Clinics of Chinese Materia Medica
基金
兰州市科技计划项目(编号:2023-2-19)
中医药人才培养重点学科项目——临床中药学:甘财社【2022】48号。
