摘要
目的为儿童患者安全使用甲巯咪唑提供参考。方法回顾性分析1例甲巯咪唑致甲状腺功能亢进症儿童患者关节炎综合征的临床资料与治疗过程,总结其临床特征,进行关联性评价,并提出针对性的处理策略。结果甲巯咪唑致关节炎综合征的临床特征为多发于女性患儿,一般在用药后2个月内发病,且常呈剂量依赖性,大剂量更易诱发。诺氏(Naranjo´s)评估量表评分为6分,关联性评价结果为“很可能”。其防治措施主要有关注女性患儿使用甲巯咪唑期间的关节疼痛症状;一旦确诊,应尝试减量或停用,并采用非甾体抗炎药或小剂量激素对症治疗。结论甲巯咪唑致儿童关节炎综合征少见,用药期间应加强用药监护及风险识别,并及时予针对性处理,保证临床用药的安全性和有效性。
Objective To provide a reference for the safe use of methimazole in children.Methods A retrospective analysis was conducted on the clinical data and treatment process of methimazole-induced arthritis syndrome in a child with hyperthyroidism.The clinical characteristics were summarized,and a correlation evaluation was conducted to propose targeted treatment strategies.Results The clinical characteristics of methimazole-induced arthritis syndrome were more common in female children,usually onset within 2 months after medication,and often dose-dependent,with high doses more likely to induce.The Naranjo´s Rating Scale score was six points,and the association evaluation result was"probable likely".The prevention and treatment measures mainly focused on joint pain symptoms during the use of methimazole in the female child.Once diagnosed,attempts should be made to reduce or discontinue methimazole,and symptomatic treatment with nonsteroidal anti-inflammatory drugs or low-dose steroids should be used.Conclusion The incidence of methimazole-induced arthritis syndrome in children is rare.During the medication,medication monitoring and risk identification should be strengthened,and targeted treatment should be given in time to ensure the safety and effectiveness of clinical medication.
作者
刘佳
赵珊
张宝
陈婷婷
杨红
李悦
LIU Jia;ZHAO Shan;ZHANG Bao;CHEN Tingting;YANG Hong;LI Yue(Guiyang Maternal and Child Health Care Hospital,Guiyang,Guizhou 550003,China)
出处
《中国药业》
2026年第1期130-133,共4页
China Pharmaceuticals
基金
贵州省卫生健康委员会科学技术基金项目[gzwkj2023-084]。
关键词
甲巯咪唑
关节炎综合征
儿童
回顾性分析
临床特征
处理策略
methimazole
arthritis syndrome
children
retrospective analysis
clinical characteristics
treatment strategy
