摘要
很多皮肤不适症状的产生均与外界环境因素如光照、污染物、化妆品刺激成分等有直接关系,其引发产生的活性氧(ROS)是诱发皮肤损伤的起始信号。总结了由ROS引发的氧化应激反应通过酶损伤、细胞结构损伤、炎症性反应等损伤皮肤的多条途径,以及氧化损伤引起的皮肤衰老、敏感、暗沉等症状。重点介绍了皮肤自身抗氧化屏障系统的特点及其抗氧化作用机制,并提出维持和增强皮肤自身抗氧化屏障系统,以及强化皮肤角质层外层抗氧化防护的护肤策略。
Many skin discomfort symptoms are directly related to external environmental factors such as sunlight,pollutants,and irritating ingredients in cosmetics.These factors generate reactive oxygen species(ROS),which serve as the initial signal triggering skin damage.The multiple pathways through which ROS-induced oxidative stress damaged the skin,including enzyme damage,cellular structural damage,and inflammatory responses,as well as the skin ageing,sensitivity,and dullness symptoms resulting from oxidative damage were summarized in this paper.The characteristics and antioxidant mechanisms of the skin's own antioxidant barrier system were highlighted,and strategies for maintaining and enhancing the skin's antioxidant barrier system,as well as antioxidant protection of the outer layer of the skin's stratum corneum,were proposed.
作者
吕永博
曲召辉
宋阳
李姝静
吴珂
何一凡
LYU Yongbo;QU Zhaohui;SONG Yang;LI Shujing;WU Ke;HE Yifan(Beijing WeYep Innovation Technology Co.,Ltd.,Beijing 100048,China;School of Light Industry Science and Engineering,Beijing Technology and Business University,Beijing 100048,China;Frontier Interdisciplinary Research Institute,Beijing Technology and Business University,Beijing 100048,China)
出处
《香料香精化妆品》
2025年第5期23-30,共8页
Flavour Fragrance Cosmetics
基金
国家自然科学基金资助项目(编号22301012)
北京市教育委员会科研计划项目(编号KM202310011005)
北京市科协青年人才托举工程(编号BYESS2024051)。
关键词
活性氧
氧化应激
DNA损伤
皮肤屏障
抗氧化剂
角化包膜
reactive oxygen species
oxidative stress
DNA damage
skin barrier
antioxidant
keratinizing envelope
