摘要
RNA特异性腺苷脱氨酶(Adenosine deaminases acting on RNA,ADAR)蛋白家族广泛分布于脊椎动物与无脊椎动物中。目前,脊椎动物ADAR的功能研究已较为系统和深入,诸多研究指出了其在免疫调控、病毒防御、癌症治疗以及神经发育等多个领域发挥的关键作用。本文归纳了无脊椎动物ADAR研究中的关键问题,重点聚焦于其结构特征、表达模式、RNA编辑情况,以及在免疫和神经发育方面的功能。分析表明,无脊椎动物ADAR与脊椎动物ADAR具有相似的功能,这充分体现了ADAR在无脊椎与脊椎动物之间功能的高度保守性。在此基础上,本文对无脊椎动物ADAR的系统演化规律及其在跨物种适应性中的分子机制研究前景进行了展望,以期为深入解析ADAR家族的进化保守性与功能多样性提供理论参考。
Adenosine deaminases acting on RNA(ADARs)protein family is widely distributed among both vertebrates and invertebrates.At present,the functions of ADAR in vertebrates have been systematically and extensively studied.Numerous studies have highlighted its critical roles in immune regulation,antiviral defense,cancer therapy,and neurodevelopment.This paper summarizes key issues in the study of ADAR in invertebrates,with a focus on its structural features,expression patterns,RNA editing activity,and functions in immunity and neurodevelopment.The analysis indicates that invertebrate ADAR shares similar functions with vertebrate ADAR,fully demonstrating the high degree of functional conservation of ADAR between invertebrates and vertebrates.On this basis,the paper also discusses the prospects for research on the evolutionary patterns of invertebrate ADAR and its molecular mechanisms underlying cross-species adaptation,aiming to provide a theoretical reference for in-depth exploration of the evolutionary conservation and functional diversity of the ADAR family.
作者
李红岩
张依
Li Hongyan;Zhang Yi(Institute of Evolution and Marine Biodiversity,College of Marine Life Sciences,Ocean University of China,Qingdao 266003,China)
出处
《中国海洋大学学报(自然科学版)》
北大核心
2026年第1期125-133,共9页
Periodical of Ocean University of China
基金
山东省自然科学基金项目(ZR2024MC010)资助。
