摘要
目的:探讨血清25-羟基维生素D[25(OH)D]、血管紧张素Ⅱ受体样1内源性配体13(Apelin-13)在儿童肾病综合征(NS)激素治疗反应监测中的临床意义。方法:选取2022年3月至2024年6月本院儿科收治的153例NS患者作为研究对象。比较NS患儿激素治疗前、治疗4周后25(OH)D、Apelin-13水平;统计NS患儿激素治疗反应结果,并根据结果将患儿分为激素敏感组和激素耐药组;分析影响NS患儿激素治疗反应的单因素及多因素。结果:NS患儿激素治疗后的血清25(OH)D、Apelin-13水平均高于治疗前,差异均有统计学意义(P<0.05)。153例NS患儿经过泼尼松治疗后,存在激素敏感患儿127例(83.01%),纳入激素敏感组;存在激素耐药患儿26例(16.99%),纳入激素耐药组。激素敏感组患儿血清25(0H)D、Apelin-13水平高于激素耐药组,差异均有统计学意义(P<0.05)。经二元Logistic回归分析结果显示:25(OH)D、Apelin-13均是影响NS患儿激素治疗反应的危险因素(P<0.05)。结论:25(OH)D、Apelin-13对NS患儿激素治疗反应具有重要的参考价值,可为制定临床治疗方案提供一定依据。
Objective:To explore the clinical significance of serum 25-hydroxy vitamin D[25(OH)D]and angiotensin Il Receptor-like 1 endogenous ligand 13(Apelin-13)in the monitoring of hormone therapy response in children with nephrotic syndrome(NS).Methods:A total of 153 children with NS admitted to our hospital from March 2022 to June 2024 were selected as the study subjects.The levels of 25(OH)D and Apelin-13 in children with NS before and after 4 weeks of hormone therapy were compared.The responses of children with NS to hormone treatment were statistically analyzed,and classify the children into hormone-sensitive group and hormone-resistant group based on the results.The univariate and multivariate factors affecting the response to hormone therapy in children with NS were analyzed.Results:The levels of serum 25(OH)D and Apelin-13 in children with NS after hormone therapy were higher than those before treatment,and the difference was statistically significant(P<0.05).After prednisone treatment,there were 127 patients(83.01%)with hormone sensitivity,included in hormone sensitive group,and 26 patients(16.99%)with hormone resistance,included in hormone resistant group.The levels of serum 25(OH)D and Apelin-13 in hormone sensitive group were higher than those in hormone resistant group,and the differences were statistically significant(P<0.05).Binarylogistic regression analysis showed that 25(OH)D and Apelin-13 were the risk factors affecting the response of NS children to hormone therapy(P<0.05).Conclusion:25(0H)D and Apelin-13 have important reference value for the response of hormone therapy in children with NS,which can provide a basis for the formulation of clinical treatment plan.
作者
栾晓飞
王鹏
温淑娟
LUAN Xiaofei;WANG Peng;WEN Shujuan(Department of Pediatrics,Puyang People's Hospital of Henan Province,Puyang 457000,China)
出处
《四川解剖学杂志》
2025年第3期104-106,共3页
Sichuan Journal of Anatomy
