摘要
目的:探讨不同剂量瑞舒伐他汀联合双抗血小板药物治疗对急性脑梗死(ACI)患者血脂及神经功能的影响.方法:选取2022年1月至2025年1月本院收治的104例ACI患者为研究对象.按随机数字表法,将其分为研究组(n=52,采用大剂量瑞舒伐他汀联合双抗血小板药物治疗)和对照组(n=52,采用小剂量瑞舒伐他汀联合双抗血小板药物治疗),两组患者均持续治疗1个月.比较两组患者临床疗效、治疗前后血脂水平、神经功能及不良反应.结果:研究组患者治疗总有效率高于对照组,差异有统计学意义(P<0.05).治疗后,研究组患者总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白(LDL-C)水平以及美国国立卫生院脑卒中量表(NIHSS)评分均低于对照组,差异均有统计学意义(P<0.05).两组患者不良反应总发生率比较,差异无统计学意义(P>0.05).结论:相较于小剂量瑞舒伐他汀联合双抗血小板药物,大剂量瑞舒伐他汀联合双抗血小板药物在ACI中的应用效果更为显著,可有效降低患者血脂指标,促进患者神经功能恢复,且安全性较好.
Objective:To explore the effect of different doses of rosuvastatin combined with bispecific antiplatelet agents therapy on blood lipid and nerve function in patients with acute cerebral infarction(ACI).Methods:A total of 104 patients with ACI admitted to our hospital from January 2022 to January 2025 were selected as the study subjects.They were divided into study group(n=52,treated with high-dose rosuvastatin and bispecific antiplatelet agents)and control group(n=52,treated with low-dose rosuvastatin and bispecific antiplatelet agents)according to the random number table method,both groups continued treatment for 1 month.The clinical efficacy,blood lipid level,neurological function and adverse reactions before and after treatment were compared between the two groups.Results:The total effective rate of study group was higher than that of control group,and the difference was statistically significant(P<0.05).After treatment,the levels of total cholesterol(TC),triglyceride(TG),low-density lipoprotein cholesterol(LDL-C)and the National Institutes of Health stroke scale(NIHSS)score of study group were lower than those of control group,and the differences were statistically significant(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion:Compared with low-dose rosuvastatin combined with bispecific antiplatelet agents,high-dose rosuvastatin combined with bispecific antiplatelet agents has a more significant application effect in ACI,which can more effectively reduce the blood lipid index of patients and promote the recovery of neurological function of patients,with good safety.
作者
王光辉
陈泓烨
WANG Guanghui;CHEN Hongye(Department of Neurology,Tongxu First Hospital,Kaifeng 475499,China)
出处
《四川解剖学杂志》
2025年第3期97-100,共4页
Sichuan Journal of Anatomy
关键词
急性脑梗死
瑞舒伐他汀
不同剂量
抗血小板治疗
血脂
神经功能
Acute cerebral infarction
Rosuvastatin
Different doses
Antiplatelet therapy
Blood lipid
Neural function
