摘要
缺血性脑卒中的临床疗效因神经保护剂难以跨越血脑屏障靶向递送至缺血区而受到严重限制。脂质体凭借其独特的双分子层结构,可同时包载亲水性与疏水性药物,并兼具优异的生物相容性、可修饰性及高效穿透血脑屏障的能力,成为突破缺血性脑卒中治疗药物递送瓶颈的关键策略。该文系统性综述脂质体的结构特性、靶向递送机制及近10年来在缺血性脑卒中治疗中的前沿应用,重点探讨表面修饰型脂质体通过主动/被动靶向协同策略实现神经保护剂在缺血区域的精准蓄积,尤其是在搭载中药活性成分方面;深入解析修饰型脂质体在抑制神经炎症、减轻缺血/再灌注损伤、联合组织纤溶酶原激活剂及仿生修饰递送系统的最新进展;为缺血性脑卒中的精准化与个体化治疗提供新的理论框架,并为基于脂质体技术的神经保护剂递送系统开发提供参考。
The clinical efficacy of ischemic stroke is severely limited by the difficulty in targeted delivery of neuroprotective agents across the blood-brain barrier to the ischemic region.Liposomes,with their unique bilayer structure,can carry both hydrophilic and hydrophobic drugs and have excellent biocompatibility,modifiability,and high efficiency in crossing the blood-brain barrier,which have become a key strategy to break through the bottleneck of drug delivery in ischemic stroke treatment.This paper systematically reviews the structural properties of liposomes,their targeted delivery mechanisms,and their cutting-edge applications in ischemic stroke therapy in the past decade,focusing on the precise accumulation of neuroprotective agents in the ischemic region by surface-modified liposomes through the synergistic strategy of active/passive targeting,especially in piggybacking on the active ingredients of TCM.The paper analyzes in depth the latest advances of modified liposomes in inhibiting neuroinflammation,attenuating ischemia/reperfusion injury,combining with tissue plasminogen activator and biomimetic modification of delivery systems.It aims to provide a new theoretical framework for the precise and individualized treatment of ischemic stroke and to provide a reference for the development of neuroprotective agent delivery systems based on liposome technology.
作者
董佳豪
高子涵
韩飞
刘明睿
钱冰露
曹雯萱
刘应蛟
DONG Jia-hao;GAO Zi-han;HAN Fei;LIU Ming-rui;QIAN Bing-lu;CAO Wen-xuan;LIU Ying-jiao(School of Pharmacy,Jiangxi University of Chinese Medicine,Nanchang 330004,China)
出处
《中国中药杂志》
北大核心
2025年第22期6205-6214,共10页
China Journal of Chinese Materia Medica
基金
国家自然科学基金项目(82360782)
江西省自然科学基金项目(20232BAB206170)
江西省中医药管理局科技计划项目(2021A333)
江西省卫生健康委科技计划项目(202211412)
江西中医药大学国家级大学生创新创业训练计划,江西省“十四五”期间药学一流专业建设经费项目(202410412036)。
关键词
脂质体
缺血性脑卒中
血脑屏障
组织纤溶酶原激活剂
仿生修饰
liposome
ischaemic stroke
blood-brain barrier
tissue plasminogen activator
biomimetic modification
