摘要
Immune reconstitution inflammatory syndrome(IRIS)is a collection of inflammatory disorders characterized by the paradoxical worsening of preexisting infections processes following the initiation of antiretroviral therapy in human immunodeficiency virus(HIV)-infected individuals.Diagnosing IRIS accurately and promptly remains challenging in areas with limited medical resources.Herpes simplex virus-2(HSV-2)is highly endemic in sub-Saharan Africa and is one of the primary opportunistic pathogens underlying IRIS,manifesting as mucocutaneous lesions.Here,we report a case of HSV-2-associated IRIS presenting as a genital ulcer,confirmed through nanopore high-throughput sequencing and successfully treated with acyclovir antiviral therapy.This study emphasizes the importance of clinicians maintaining proficiency in recognizing IRIS manifestations and being aware of region-specific opportunistic pathogens,both essential for timely diagnosis and etiology-directed therapy.
基金
supported by National key R&D Program of China(2024YFC2311100)
the National Social Science Fund of China(2022-SKJJ-B-069).
