摘要
目的探究中性粒细胞与淋巴细胞比率(NLR)对早期预测早产儿视网膜病(ROP)的价值。方法回顾性收集2019年1月1日至12月31日郑州大学第一附属医院新生儿科收治的胎龄小于32周早产儿的临床数据,根据ROP筛查结果分为ROP组和未发生ROP的对照组。收集患儿7~10日龄时的血常规结果,包括白细胞、中性粒细胞、淋巴细胞、单核细胞及血小板计数,计算NLR、淋巴细胞与单核细胞比值(LMR)、血小板与淋巴细胞比值(PLR)。使用Logistic回归分析评估影响ROP发生的危险因素,利用受试者工作特征曲线分析NLR早期预测ROP的价值。结果共纳入325例新生儿,其中110例(33.8%)患有ROP,215例(66.2%)未诊断ROP。ROP组的胎龄和出生体重均小于对照组,差异有统计学意义(P<0.05)。ROP组中血常规中性粒细胞计数和NLR高于对照组,而血小板计数、淋巴细胞计数、LMR低于对照组,差异有统计学意义(P<0.05)。多因素Logistic回归分析显示,小胎龄、低出生体重和高NLR是发生ROP的主要危险因素。NLR预测ROP的敏感性和特异性分别为90.1%、74.4%。结论出生后第1周的外周血NLR可以作为一种简单、便捷的方法,早期预测ROP的发生。
Objective To explore the value of the neutrophil-to-lymphocyte ratio(NLR)in early prediction of retinopathy of prematurity(ROP).Methods The medical records of 325 preterm infants with a gestational age<32 weeks who were admitted to the Neonatology Department of the First Affiliated Hospital of Zhengzhou University from January 1,2019 to December 31,2019 were retrospectively reviewed.The complete blood cell results at 7-10 days of age were collected,including white blood cell,neutrophil,lymphocyte,monocyte,and platelet counts.The NLR,lymphocyte-to-monocyte ratio(LMR),and platelet-to-lymphocyte ratio(PLR)were calculated.Logistic regression analysis was used to assess the risk factors associated with ROP.The receiver operating characteristic curve was performed to evaluate the value of NLR in the early prediction of ROP.Results A total of 325 infants were involved,including 110(33.8%)with ROP and 215(61.2%)without ROP.The gestational age,birth weight,platelet count,lymphocyte count,and LMR were significantly lower in the ROP group(P<0.05),whereas the neutrophil count and NLR were found to be significantly higher(P<0.05).Multivariate Logistic regression analysis revealed that small gestational age,low birth weight,and high NLR were major risk factors for the development of ROP.The sensitivity and specificity of NLR in early predicting ROP were 90.1%and 74.4%,respectively.Conclusion The NLR at the first week after birth can serve as a simple method for early prediction of the development of ROP.
作者
郭宏湘
陈静
刘丽君
程秀永
郝庆飞
Guo Hongxiang;Chen Jing;Liu Lijun;Cheng Xiuyong;Hao Qingfei(Department of Pediatrics,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450000,China)
出处
《中国小儿急救医学》
2025年第10期725-728,共4页
Chinese Pediatric Emergency Medicine
基金
吴阶平基金会临床科研专项资助基金(320.6750.2025-9-5)。
