摘要
目的:探究比索洛尔、地高辛联合治疗老年慢性心力衰竭(Chronic heart failure,CHF)伴持续性心房颤动(Atrial fibrillation,AF)临床效果。方法:选取2024年1月至2025年4月永城市人民医院收治的70例老年CHF伴持续性AF患者,随机分成对照组和实验组(n=35),分别口服常规药物联合地高辛0.125 mg(Qd),以及常规药物、地高辛0.0625 mg和比索洛尔0.625 mg(Qd)。治疗1m后,采用心电图机和超声心动图测定两组治疗前后心室率(最大、最小、平均)和心功能指标,包括左室收缩末期内径(Left ventricular end-systolic diameter,LVESD)、左室射血分数(Left ventricular ejection fraction,LVEF)、左室舒张末期内径(Left ventricular end diastolic diameter,LVEDD)。结果:治疗后,对照组和实验组老年CHF伴持续性AF患者的最大、最小、平均心室率、LVEDD和LVESD均显著降低(P<0.05),LVEF显著提高(P<0.05)。实验组老年CHF伴持续性AF患者的最大、最小、平均心室率、LVEDD和LVESD显著低于对照组(P<0.05),LVEF显著高于对照组(P<0.05)。治疗期间,两组不良反应发生率无统计学意义(P>0.05)。结论:比索洛尔、地高辛联合治疗可以有效调节老年CHF伴持续性AF患者心室率,改善心功能,且未增加不良反应发生风险。
Objective:To explore the clinical effect of bisoprolol combined with digoxin in the treatment of elderly patients with chronic heart failure(CHF)and persistent atrial fibrillation(AF).Methods:A total of 70 elderly patients with CHF complicated with persistent AF admitted to Yongcheng People’s Hospital from January 2024 to April 2025 were selected and randomly divided into control group(n=35)and experimental group(n=35),and they received oral administration of conventional drug combined with 0.125 mg of digoxin(once a day)or conventional drug,0.0625 mg of digoxin and 0.625 mg of bisoprolol(once a day)respectively.After 1 month of treatment,the ventricular rates(maximum,minimum,and average)as well as cardiac function indexes,including left ventricular end-systolic diameter(LVESD),left ventricular ejection fraction(LVEF),and left ventricular end-diastolic diameter(LVEDD),were measured by an electrocardiogram machine and echocardiography before and after treatment in the two groups.Results:After treatment,the maximum,minimum,and average ventricular rates,LVEDD,and LVESD of elderly CHF patients with persistent AF in the control group and experimental group were significantly decreased(P<0.05),while LVEF was significantly increased(P<0.05).The maximum,minimum,and average ventricular rates,LVEDD,and LVESD of elderly CHF patients with persistent AF were obviously lower(P<0.05),while the LVEF was significantly higher in the experimental group(P<0.05).During treatment,no statistical significance was found in the incidence of adverse reactions between groups(P>0.05).Conclusion:Bisoprolol combined with digoxin can effectively regulate the ventricular rate and improve cardiac function in elderly CHF patients with persistent AF,without increasing the risk of adverse reactions.
作者
翟平平
Zhai Ping-ping(Department of Cardiovascular Medicine,Yongcheng People's Hospital,Yongcheng 476600,Henan,China)
关键词
比索洛尔
地高辛
老年
慢性心力衰竭
持续性心房颤动
Bisoprolol
Digoxin
Elderly
Chronic heart failure
Persistent atrial fibrillation
