摘要
目的:探究调Q激光联合微针及重组胶原蛋白敷料治疗对女性黄褐斑患者皮肤美学效果及皮肤屏障功能的影响。方法:选取2020年9月-2023年1月于笔者医院进行治疗的稳定期黄褐斑患者118例,采用随机数字表法将其随机分为联合组和单用组,各59例。单用组患者给予微针导入法,联合组患者在单用组基础之上联合调Q激光。比较两组患者治疗疗效,治疗前后,检测丙二醛(Malondialdehyde,MDA)、超氧化物歧化酶(Superoxide Dismutase,SOD)和过氧化氢酶(Catalase,CAT)水平。皮肤美学效果[皮肤黑素指数(Skin Melanin Index,MI)、红斑指数(Erythema Index,EI)]、皮肤屏障功能[皮脂含量、角质层含水量和经表皮水分流失值(Transepidermal Water Loss,TEWL)]。结果:治疗后,联合组患者治疗总有效率显著高于单用组;治疗后,两组患者MDA、MI、EI、TEWL均降低,皮脂分泌含量、角质层水分含量、SOD、CAT水平均上升,联合组MDA、MI、EI、TEWL较单用组患者更低,皮脂分泌含量、角质层水分含量、SOD、CAT水平更高(P<0.05)。结论:调Q激光联合微针及重组胶原蛋白敷料治疗能够提高稳定期黄褐斑患者临床疗效,有效减轻患者皮肤色素沉着和红斑、提高抗氧化酶活性,促进皮肤屏障功能恢复。
Objective To explore the influence of Q-switched laser combined with microneedle introduction therapy and reconstituted collagen dressing on skin aesthetic effect and skin barrier function in patients with chloasma.Methods 118 patients with stable chloasma who were treated in the hospital were selected from September 2020 to January 2023,and were randomly divided into combined group and single group by adopting random number table method,with 59 cases in each group.The patients in the single group were given microneedle introduction and reconstituted collagen dressing,while the patients in the combined group were combined with Q-switched laser on the basis of the single group.The therapeutic efficacy was compared between groups.The levels of malondialdehyde(MDA),superoxide dismutase(SOD)and catalase(CAT),skin cosmetic effect[skin melanin index(MI),erythema index(EI)]and skin barrier function[sebum content,water content of stratum corneum and transepidermal water loss(TEWL)]were detected before and after treatment.Results After treatment,the total efective rate of treatment in combined group was significantly higher than that in single group.The MDA,MI,EI and TEWL in the two groups after treatment were decreased while the sebum secretion content,water content of stratum corneum,SOD and CAT were increased,and the MDA,MI,EI and TEWL were lower while the sebum secretion content,water content of stratum corneum,SOD and CAT were higher(P<0.05).Conclusion Q-switched laser combined with microneedle introduction therapy and reconstituted collagen dressing can improve the clinical efficacy of patients with stable chloasma,efectively relieve the skin pigmentation and erythema,enhance the antioxidant enzyme activity,and promote the recovery of skin barrier function.
作者
张兴露
邓超
宁旭
ZHANG Xinglu;DENG Chao;NING Xu(Department of Dermatology and Venereology,Dujiangyan People's Hospital(Dujiangyan Medical Centre),Chengdu 611830,Sichuan,China)
出处
《中国美容医学》
2026年第1期108-112,共5页
Chinese Journal of Aesthetic Medicine
关键词
黄褐斑
调Q激光
微针导入
皮肤美学效果
皮肤屏障功能
chloasma
Q-switched laser
microneedle introduction
skin aesthetic effect
skin barrier function
