摘要
目的:探讨创面周围注射富血小板血浆(PRP)对慢性难愈性创面的修复效果及对炎症反应和疼痛的影响。方法:选取2022年1月-2024年1月笔者科室收治的120例慢性难愈性创面患者为研究对象,依照就诊顺序,在采纳患者意愿的基础上,根据治疗方法结合随机数字表法分为传统组和PRP组,各60例。传统组采用常规清创换药治疗,PRP组在传统组基础上创面周围注射PRP。对比两组炎症指标[白细胞(WBC)计数、C反应蛋白(CRP)水平、红细胞沉降率(ESR)]、创面疼痛情况[疼痛视觉模拟量表(VAS)]、创面修复因子水平[血管内皮生长因子(VEGF)、表皮生长因子(EGF)、碱性成纤维细胞生长因子(bFGF)、血小板衍生生长因子(PDGF)]、细菌培养阳性情况、临床综合疗效、不良反应发生情况及患者满意度。结果:治疗后,PRP组在炎症指标(WBC、CRP、ESR)、VAS疼痛评分及创面修复因子水平(VEGF、EGF、bFGF、PDGF)的改善幅度均优于传统组(P<0.05),且PRP组细菌培养阳性率更低(P<0.05)。PRP组临床疗效总有效率与患者满意度均高于传统组(P<0.05)。两组均未出现不良反应。结论:PRP创面周围注射治疗慢性难愈性创面疗效显著,可有效减轻患者炎症反应,缓解疼痛症状,提高创面内生长因子的浓度,促进创面愈合,安全有效,患者满意度高,具有临床推广应用价值。
Objective To investigate the efect of periwound injection of platelet-rich plasma(PRP)on the repair of chronic refractory wounds and the efect on inflammation and pain.Methods A total of 120 patients with chronic refractory wounds admitted to our department from January 2022 to January 2024 were selected as the research objects.According to the order of treatment and on the basis of adopting the wishes of patients,they were divided into traditional group and PRP group according to the random number table method,with 60 cases in each group.Patients in traditional group were treated with conventional debridement and dressing change,and patients in PRP group were injected with PRP around the wound on the basis of traditional group.The inflammatory indicators[white blood cell(WBC)count,C-reactive protein(CRP)level,erythrocyte precipitation rate(ESR)],wound pain[visual analogue scale for pain(VAS)],wound repair factor levels[vascular endothelial growth factor(VEGF),epidermal growth factor(EGF),basic fibroblast growth factor(bFGF),platelet-derived growth factor(PDGF)],positive bacterial culture,clinical comprehensive efficacy and adverse reactions and patient satisfaction were compared between the two groups.Results After treatment,the improvement of inflammatory indexes(WBC,CRP,ESR),VAS pain score and wound repair factor levels(VEGF,EGF,bFGF,PDGF)in PRP group were better than those in traditional group(P<0.05),and the positive rate of bacterial culture in PRP group was lower than that in traditional group(P<0.05).The total efective rate of clinical efficacy and patient satisfaction in PRP group were higher than those in traditional group(P<0.05).There were no adverse reactions in the two groups.Conclusion PRP periwound injection is effective in the treatment of chronic refractory wounds,which can efectively reduce the inflammatory response of patients,relieve pain symptoms,improve the concentration of growth factors in the wound,promote wound healing,is safe and efective,with high patient satisfaction,and has clinical application value.
作者
陈思思
李兴波
赵霖
唐思瑶
CHEN Sisi;LI Xingbo;ZHAO Lin;TANG Siyao(Department of Burn and Plastic Surgery,Wenjiang Hospital,Sichuan Provincial People's Hospital,Chengdu 611100,Sichuan,China;Department of Orthopedics,Wenjiang Hospital,Sichuan Provincial People's Hospital,Chengdu 611100,Sichuan,China)
出处
《中国美容医学》
2026年第1期53-57,共5页
Chinese Journal of Aesthetic Medicine
基金
2022年四川省医学会伤口疾病(泰阁)专项科研课题(编号:2022TG25)。
