摘要
目的探讨氧化应激评分对急性心肌梗死(acute myocardial infarction,AMI)介入治疗患者的临床意义和应用价值。方法回顾性分析2020年1月至2021年12月在铜仁市人民医院接受介入治疗的AMI患者的临床资料,根据氧化应激评分中位值将患者分为低氧化应激评分组和高氧化应激评分组。采用χ2检验或Fisher's精确检验比较两组患者的血常规、凝血功能、心脏标志物和血液生化等指标,并应用单因素和多因素Logistic回归分析AMI介入治疗患者预后不良的危险因素。结果共纳入511例患者,其中男性371例(72.60%)、女性140例(27.40%)。低氧化应激评分组和高氧化应激评分组在红细胞、纤维蛋白降解产物、脑利钠肽前体、肌钙蛋白T、肌红蛋白、血尿素氮、直接胆红素、白蛋白和胆固醇等方面的差异均具有统计学意义(P<0.05)。多因素Logistic回归分析结果显示,高氧化应激评分(OR=1.754,95%CI:1.147~2.684,P=0.01)是AMI介入治疗患者预后不良的危险因素。结论本研究揭示了氧化应激评分对于AMI患者介入治疗预后预测具有重要临床意义和应用价值。
Objective To explore the clinical significance and application value of oxidative stress score in patients with acute myocardial infarction(AMI)undergoing interventional therapy.Methods The clinical data of AMI patients who received interventional therapy in Tongren People's Hospital from January 2020 to December 2021 were retrospectively analyzed.The patients were divided into the low oxidative stress score group and the high oxidative stress score group according to the median value of oxidative stress score.The indicators such as blood routine,coagulation function,cardiac markers and blood biochemistry of the two groups of patients were compared by χ^(2) test or Fisher's exact test.Univariate and multivariate Logistic regression analyses were applied to analyze the risk factors for poor prognosis in AMI patients undergoing interventional therapy.Results A total of 511 patients were included,among whom 371 were male(72.60%)and 140 were female(27.40%).There were statistically significant differences between the low oxidative stress score group and the high oxidative stress score group in terms of red blood cells,fibrin degradation products,brain natriuretic peptide precursors,troponin T,myoglobin,blood urea nitrogen,direct bilirubin,albumin and cholesterol,etc.(P<0.05).The results of multivariate Logistic regression analysis showed that high oxidative stress score(OR=1.754,95%CI:1.147-2.684,P=0.01)was a risk factor for poor prognosis in AMI patients undergoing interventional therapy.Conclusion This study elucidated that oxidative stress score demonstrated significant clinical significance and application value for predicting the prognosis of interventional therapy in AMI patients.
作者
田华
杨良
张勇
刘芳
TIAN Hua;YANG Liang;ZHANG Yong;LIU Fang(Department of Clinical Laboratory,Tongren People’s Hospital,Tongren 554300,Guizhou Province,China)
出处
《数理医药学杂志》
2025年第12期910-922,共13页
Journal of Mathematical Medicine
基金
国家重点研发计划项目(2019YFF0216502)。
关键词
急性心肌梗死
氧化应激评分
经皮冠状动脉介入术
预后
Acute myocardial infarction
Oxidative stress score
Percutaneous coronary intervention
Prognosis
