摘要
目的:探讨阿托伐他汀钙治疗动脉粥样硬化的临床效果。方法:将72例动脉粥样硬化患者纳入研究,均为2023年5月—2024年5月上海市徐汇区枫林街道社区卫生服务中心收治,将患者随机分为两组。对照组36例,采用常规治疗方案;观察组36例,在对照组基础上联合阿托伐他汀钙治疗。对比两组血脂水平、炎性因子水平、治疗效果、不良反应发生率。结果:与治疗前相比,两组治疗后的高密度脂蛋白水平升高,甘油三酯、总胆固醇、低密度脂蛋白胆固醇、降钙素原、白细胞介素-6、C反应蛋白、肿瘤坏死因子-α水平下降,且与对照组相比,观察组各指标改善更显著(P<0.001)。相比于对照组,观察组治疗效果更好(P=0.041)。两组不良反应总发生率对比,无统计学差异(P>0.05)。结论:阿托伐他汀钙治疗动脉粥样硬化的临床效果较好,能够降低血脂水平,减轻炎性反应,且安全性较高。
Objective:To investigate the clinical effect of atorvastatin calcium in the treatment of atherosclerosis.Methods:A total of 72 patients with atherosclerosis were included in the study.All were treated at the Fenglin Subdistrict Community Health Service Center in Xuhui District of Shanghai,from May 2023 to May 2024.Patients were randomly divided into two groups.The control group consisted of 36 patients who received the conventional treatment plan,while the observation group also had 36 patients who received atorvastatin calcium in addition to the treatment given to the control group.Compare the lipid levels,inflammatory factor levels,treatment outcomes,and incidence of adverse reactions between the two groups.Result:Compared with before treatment,both groups showed an increase in high-density lipoprotein levels after treatment,while triglycerides,total cholesterol,low-density lipoprotein cholesterol,procalcitonin,interleukin-6,C-reactive protein,and tumor necrosis factor-αlevels decreased.Moreover,compared with the control group,the improvement in each indicator was more significant in the observation group(P<0.001).The treatment effect was better in the observation group than in the control group(P=0.041).There was no statistically significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion:Atorvastatin calcium has a good clinical effect in the treatment of atherosclerosis,and can reduce blood lipid levels and alleviate inflammatory response with high safety.
作者
须添翼
黄晨赟
顾磊
Xu Tianyi;Huang Chenyun;Gu Lei(Department of Pharmacy,Fenglin Subdistrict Community Health Service Center in Xuhui District of Shanghai,Shanghai 200032,China;Department of Pharmacy,Shanghai Xuhui Central Hospital,Shanghai 200031,China;Department of Pharmacy,Huashan Hospital,Fudan University,Shanghai 201100,China)
出处
《中国社区医师》
2025年第32期34-36,共3页
Chinese Community Doctors
关键词
动脉粥样硬化
阿托伐他汀钙
血脂水平
炎性因子
不良反应
Atherosclerosis
Atorvastatin calcium
Blood lipid levels
Inflammatory factor
Adverse reaction
