摘要
目的探讨含米诺环素的铋剂四联方案治疗幽门螺杆菌(HP)感染初治患者的疗效。方法选取贵州航天医院2024年7月至2025年1月收治的300例HP感染初治患者,依据治疗方案将其分成米诺环素组(n=100)、克拉霉素组(n=100)、甲硝唑组(n=100)。米诺环素组给予含米诺环素的铋剂四联方案治疗,克拉霉素组给予常规含克拉霉素的铋剂四联方案治疗,甲硝唑组给予常规含甲硝唑的铋剂四联方案治疗。比较3组临床疗效及不良反应发生情况。结果治疗14 d后,米诺环素组HP根除率、临床治疗总有效率[分别为88.00%(88/100)、96.00%(96/100)]均高于克拉霉素组[分别为74.00%(74/100)、81.00%(81/100)]和甲硝唑组[分别为73.00%(73/100)、83.00%(83/100)],差异均有统计学意义(χ^(2)=8.288、11.481,均P<0.05);克拉霉素组与甲硝唑组HP根除率、临床治疗总有效率比较差异无统计学意义(P>0.05)。3组不良反应发生率比较差异无统计学意义(P>0.05)。结论含米诺环素的铋剂四联方案治疗HP感染初治患者具有确切的疗效,可提高HP根除率,且安全性较好。
Objective To explore the effect of bismuth quadruple therapy containing minocycline on patients with initial treatment of Helicobacter pylori(H.pylori)infection.Methods A total of 300 patients who received initial treatment of H.pylori infection in Guizhou Aerospace Hospital between July 2024 and January 2025 were enrolled in the study and divided into the minocycline group with 100 cases,the clarithromycin group with 100 cases and the metronidazole group with 100 cases according to the treatment regimens.The minocycline group was given a bismuth quadruple therapy containing minocycline,the clarithromycin group was treated with a conventional bismuth quadruple therapy containing clarithromycin,and the metronidazole group underwent a conventional bismuth quadruple therapy containing metronidazole.The clinical curative effects and incidence of adverse reactions were compared among the three groups.Results After 14 days of treatment,the eradication rate of H.pylori and the total effective rate of clinical treatment were respectively 88.00%(88/100)and 96.00%(96/100)in the minocycline group,higher than 74.00%(74/100)and 81.00%(81/100)in the clarithromycin group and 73.00%(73/100)and 83.00%(83/100)in the metronidazole group,and there were statistically significant differences(χ^(2)=8.288,11.481,both P<0.05).There were no statistically significant differences in the eradication rate of H.pylori and the total effective rate of treatment between the clarithromycin group and the metronidazole group(P>0.05).There was no statistically significant difference in the incidence of adverse reactions among the three groups(P>0.05).Conclusion Bismuth quadruple therapy containing minocycline has definite effect in the treatment of the patients with initial treatment of H.pylori infection,and increases the eradication rate of H.pylori,demonstrating a favorable safety profile.
作者
龚明素
杨波
黄晶晶
陈光玉
吴琴
李兴洁
GONG Mingsu;YANG Bo;HUANG Jingjing;CHEN Guangyu;WU Qin;LI Xingjie(Department of Gastroenterology,Guizhou Aerospace Hospital,Zunyi 563000,China)
出处
《中国药物应用与监测》
2025年第9期1533-1536,共4页
Chinese Journal of Drug Application and Monitoring
基金
合肥市科技计划项目[遵市科合HZ字(2024)109号]。
关键词
幽门螺杆菌
初治
米诺环素
铋剂
四联方案
Helicobacter pylori
initial treatment
minocycline
bismuth
quadruple therapy
