摘要
目的:旨在评估中重度低钠血症住院患者的临床特征及病情转归,为本地低钠血症的临床诊治提供初步资料。方法:本研究纳入2023年1—6月在新疆维吾尔自治区人民医院就诊且血清Na^(+)<130 mmol/L的患者,按照Na^(+)浓度分为中度(125~129 mmol/L)及重度(<125 mmol/L)低钠血症组,分析2组临床资料及转归。结果:(1)中重度低钠血症患者均以老年人为多、重度低钠血症组以女性为多(P<0.05);(2)中度低钠血症组与重度低钠血症组在尿素氮、总胆红素、直接胆红素、血清钠、血清镁、血清氯、血沉、凝血酶原时间的差异有统计学意义(P<0.05);(3)总胆固醇、甘油三酯、血清氯、C反应蛋白、血沉及纤维蛋白原与Na^(+)浓度呈正相关,总胆红素、直接胆红素及活化部分凝血活酶时间与Na^(+)浓度呈负相关(P<0.05);(4)中重度低钠血症常见病因均为肺部疾病、恶性肿瘤、心脏系统疾病(P>0.05);(5)中重度低钠血症住院患者死亡率高达5.4%,入重症监护室(Intensive Care Unit,ICU)的比例高达21.8%,重度低钠血症患者中入ICU比例明显高于中度低钠血症。结论:临床医师需监测血清钠相关指标和病因,以降低患者不良预后风险。
Objective:To evaluate the clinical characteristics,etiologies,and outcomes of hospitalized patients with moderate to severe hyponatremia,and to provide preliminary data for the clinical diagnosis and treatment of hyponatremia in the local population.Methods:This study included patients who were hospitalized at Xinjiang Uyghur Autonomous Region People's Hospital between January and June 2023 with serum sodium(Na^(+))levels below 130 mmol/L.Patients were classified into moderate(125~129 mmol/L)and severe(<125 mmol/L)hyponatremia groups based on Na^(+)concentration,and their clinical data and outcomes were analyzed.Results:(1)Patients with moderate to severe hyponatremia were predominantly elderly,with a significantly higher proportion of females in the severe hyponatremia group(P<0.05).(2)Significant differences between the moderate and severe groups were observed in blood urea nitrogen,total bilirubin,direct bilirubin,serum sodium,serum magnesium,serum chloride,erythrocyte sedimentation rate,and prothrombin time(P<0.05).(3)Total cholesterol,triglycerides,serum chloride,C-reactive protein,erythrocyte sedimentation rate,and fibrinogen were positively correlated with serum sodium concentration,while total bilirubin,direct bilirubin,and activated partial thromboplastin time were negatively correlated(P<0.05).(4)The most common etiologies of moderate to severe hyponatremia were pulmonary diseases,malignancies,and cardiovascular disorders(P>0.05).(5)The overall mortality rate among hospitalized patients with moderate to severe hyponatremia was 5.4%,and 21.8%required intensive care unit(ICU)admission.The proportion of ICU admissions was significantly higher in the severe hyponatremia group compared with the moderate group.Conclusions:Clinicians should closely monitor serum sodium levels and related indicators,as well as identify underlying etiologies,to reduce the risk of adverse outcomes in patients with hyponatremia.
作者
段丽侠
胡延
马睿
苏比努尔·吐尼亚孜
张凯迪
郭艳英
DUAN Lixia;HU Yan;MA Rui;SUBINUR·Tuniyazi;ZHANG Kaidi;GUO Yanying(Shihezi University School of Medicine,Shihezi,Xinjiang 832003,China;Department of Endocrine and Metabolic Diseases,People's Hospital of Xinjiang Uygur Autonomous Region,Urumqi 830000,China)
出处
《农垦医学》
2025年第6期513-518,共6页
Journal of Nongken Medicine
基金
国家自然科学基金(81860148)。
关键词
低钠血症
临床特征
转归
回顾性研究
Hyponatremia
Clinical characteristics
Outcomes
Retrospective study
