摘要
免疫炎症反应贯穿于肝损伤的整个病理过程,然而其具体调控机制尚未完全阐明。近年研究发现,Notch信号通路通过调控巨噬细胞极化、中性粒细胞募集活化及调节性免疫细胞分化等方式,在肝损伤中发挥重要作用。本文系统梳理了Notch信号通路介导免疫炎症反应参与肝损伤的分子机制并总结归纳,旨在为肝脏疾病免疫炎症损伤分子机制的阐明提供新视角,并为未来研究方向提供新的参考。
Immune inflammatory response runs through the whole pathological process of liver injury,but its specific regulatory mechanism remains unclear.Recent studies have shown that the Notch signaling pathway plays an important role in liver injury by regulating macrophage polarization,activating neutrophil recruitment,and modulating the differentiation of regulatory immune cells.This article systematically reviews the molecular mechanisms of the Notch signaling pathway in mediating immune inflammatory response in liver injury,in order to provide new perspectives for clarifying the molecular mechanism of immune inflammatory damage in liver diseases,as well as a new reference for future research directions.
作者
舒发明
黄英
张衎
何发娟
龙富立
毛德文
SHU Faming;HUANG Ying;ZHANG Kan;HE Fajuan;LONG Fuli;MAO Dewen(Department of Hepatology,The First Affiliated Hospital of Guangxi University of Chinese Medicine,Nanning 530023,China;Department of Traditional Chinese Medicine,International Zhuang Medical Hospital Affiliated to Guangxi University of Chinese Medicine,Nanning 530200,China)
出处
《临床肝胆病杂志》
北大核心
2025年第11期2424-2428,共5页
Journal of Clinical Hepatology
基金
国家中医临床研究基地重点病种临床研究项目(国中医药科技函〔2018〕131号)
国家自然科学基金面上项目(82274434)
国家自然科学基金地区项目(82360912)
广西中医药多学科交叉创新团队项目(GZKJ2306)。
关键词
肝损伤
受体
Notch
病理过程
Liver Injury
Receptors,Notch
Pathologic Processes
