摘要
肝细胞癌(HCC)的发病机制涉及慢性肝损伤引发的炎症与肝纤维化,导致肝干细胞异常增殖及变异,形成肿瘤细胞。虽然HCC的西医疗法取得了较大进展,但患者5年生存率不足20%,且面临耐药性强、不良反应等局限性。近年来,中医药以其多成分、多靶点调控肿瘤微环境及信号通路的独特优势,在抗肿瘤领域的应用逐渐受到重视。Hedgehog信号通路在细胞增殖、分化及肿瘤转移中发挥重要作用,其在肝癌发生发展中的作用日益受到关注。本文综述了中药单体和中药复方靶向调控Hedgehog信号通路发挥抗HCC的机制和研究进展,旨在为中医药防治HCC提供新的思路。
The pathogenesis of hepatocellular carcinoma(HCC)involves inflammation and liver fibrosis caused by chronic liver injury,leading to the abnormal proliferation and mutation of liver stem cells and the formation of tumor cells.Although great progress has been made in Western medicine treatment of HCC,the 5-year survival rate of patients remains below 20%,with the limitations such as strong drug resistance and adverse reactions.In recent years,traditional Chinese medicine(TCM)has gradually gained attention in the field of antitumor therapy due to its unique advantages of regulating tumor microenvironment and signaling pathways through multiple components and targets.The Hedgehog signaling pathway plays an important role in cell proliferation,differentiation,and tumor metastasis,and its role in the development and progression of liver cancer has attracted more and more attention.This article reviews the mechanisms and research advances in the anti-HCC effect of TCM monomers and compound prescriptions through targeted regulation of the Hedgehog signaling pathway,in order to provide new ideas for TCM prevention and treatment of HCC.
作者
蔡修成
李晓东
CAI Xiucheng;LI Xiaodong(College of Traditional Chinese Medicine,Hubei University of Chinese Medicine,Wuhan 430061,China;Institute of Liver Diseases,Hubei Key Laboratory of Theoretical and Applied Research of Liver and Kidney in Traditional Chinese Medicine,Hubei Provincial Hospital of Traditional Chinese Medicine,Wuhan 430061,China;Hubei Shizhen Laboratory,Wuhan 430061,China)
出处
《临床肝胆病杂志》
北大核心
2025年第11期2403-2409,共7页
Journal of Clinical Hepatology
基金
湖北省公共卫生领军人才培养计划(鄂卫通〔2021〕73号)
湖北省自然科学基金(2024AFD337)。
关键词
癌
肝细胞
猬蛋白质类
信号传导
中医治疗学
Carcinoma,Hepatocellular
Hedgehog Proteins
Signal Transduction
Therapeutics(TCM)
