摘要
目的 探讨不同产气类型的小肠细菌过度生长(small intestinal bacterial overgrowth, SIBO)消化道症状差异性。方法 纳入2021年6月至2021年12月于中国人民解放军总医院第六医学中心行甲烷、氢呼气试验检测者。根据甲烷和氢呼气试验检测结果,将SIBO分为阴性组(n=300)、阳性组(n=239);分析SIBO与消化不良(积食)、反酸烧心、腹痛、腹胀、腹泻、便秘、排气增多等上下消化道症状的相关性。根据甲烷及氢呼气试验检测数值不同,将SIBO阳性组进一步分为氢阳组(n=103)、甲烷阳组(n=80)、双阳组(n=56),以SIBO阴性组为参照,分析各组间消化道症状的差异性。结果 产甲烷菌过度生长与年龄(OR=1.025,95%CI:1.001~1.050,P=0.045)、便秘(OR=2.075,95%CI:1.271~3.387,P=0.004)有关;产甲烷菌及产氢菌过度生长与BMI(OR=0.878,95%CI:0.801~0.962,P=0.005)有关。结论 产甲烷菌的过度生长与便秘呈正相关。
Objective To explore the variability of gastrointestinal symptoms of small intestinal bacterial overgrowth(SIBO)with different types of gas production.Methods Participants who underwent methane and hydrogen breath tests at the Sixth Medical Center of Chinese PLA General Hospital from Jun.2021 to Dec.2021 were included.According to the methane and hydrogen breath test results,SIBO was divided into negative group(n=300)and positive group(n=239);digestive tract symptom such as dyspepsia(accumulation of food),acid reflux and heartburn,abdominal pain,bloating,diarrhea,constipation,and increased exhaustion were analyzed between the two groups.The SIBO-positive group was further divided into three subgroups based on different methane and hydrogen levels:hydrogen-positive group(n=103),methane positive group(n=80),and both positive group(n=56),with the SIBO-negative group serving as a reference to analyze the differences in general factors and gastrointestinal symptoms among these groups.Results Overgrowth of methanogens was associated with age(OR=1.025,95%CI:1.001-1.050,P=0.045)and constipation(OR=2.075,95%CI:1.271-3.387,P=0.004);and overgrowth of both methanogens and hydrogen-producing bacteria was associated with BMI(OR=0.878,95%CI:0.801-0.962,P=0.005).Conclusion Overgrowth of methanogenic bacteria and constipation are positively associated.
作者
刘晓娜
王晓辉
王少鑫
李超
刘茜
冼锐
董昌昊
崔立红
LIU Xiaona;WANG Xiaohui;WANG Shaoxin;LI Chao;LIU Xi;XIAN Rui;DONG Changhao;CUI Lihong(Department of Gastroenterology,the Sixth Medical Center of Chinese PLA General Hospital,Beijing 100048;Graduate School of Chinese PLA Medicine College,China)
出处
《胃肠病学和肝病学杂志》
2025年第12期1764-1768,共5页
Chinese Journal of Gastroenterology and Hepatology
基金
首都卫生发展科研专项(首发2020-2-5113)。
关键词
小肠细菌过度生长
便秘
产甲烷菌
Small intestinal bacterial overgrowth
Constipation
Intestinal methanogen overgrowth
