摘要
该文报道3例食源性肉毒毒素中毒患者, 1例为散发病例, 2例为家庭同住人员, 均以视物模糊、眼睑下垂、吞咽困难起病, 进展迅速, 均出现呼吸衰竭, 1例予以无创呼吸机辅助通气, 2例给予有创呼吸机辅助通气。3例患者血清毒物检测均为A型肉毒毒素阳性。散发食源性肉毒毒素中毒与重症肌无力、吉兰-巴雷综合征早期症状、体征相似, 需予以鉴别。肉毒抗毒素血清是唯一有效的治疗方案, 在怀疑肉毒中毒的第一时间即可给予经验性抗毒素治疗。早发现、早期采取特异性的治疗对于此类患者至关重要。
This report summarized and analyzed the clinical data of 3 patients with food-borne botulism admitted to our department.One case was sporadic,while the other two involved family members living together.All patients initially presented with blurred vision,ptosis,and dysphagia,and the disease progressed rapidly.During the course of the disease,all three cases developed respiratory failure;one patient received non-invasive ventilatory support,whereas the other two required invasive ventilator assisted ventilation.The serum toxin tests of the 3 patients were all positive for botulinum toxin type A.Sporadic food-borne botulism shares similar early symptoms and signs to myasthenia gravis and Guillain-Barre syndrome,and requires careful differential diagnosis.Botulinum antitoxin serum is the only effective treatment,and empirical antitoxin administration can be initiated immediately upon suspicion of botulism.Early detection and timely specific treatment are critical for improving patient outcomes.
作者
杨辉丽
沈瑞乐
白永杰
宋亚晗
李晖
鲍盈帆
Yang Huili;Shen Ruile;Bai Yongjie;Song Yahan;Li Hui;Bao Yingfan(Department of Neurology,First Affiliated Hospital of Henan University of Science and Technology,Luoyang 471000,China)
出处
《中华全科医师杂志》
2025年第12期1545-1548,共4页
Chinese Journal of General Practitioners
