摘要
目的探讨八段锦对糖尿病高危人群口服葡萄糖耐量试验(OGTT)后血糖及胰岛素的改善效果。方法选择2022年3月至2023年5月在重庆市南岸区中西医结合医院门诊及住院部就诊的糖尿病高危人群200例,随机分为2组,最终纳入对照组92例、试验组91例。对照组接受糖尿病饮食教育和健步走干预,试验组在此基础上联合八段锦干预,持续干预52周。分别在基线、干预第26周(26周)、干预第52周(52周)进行OGTT,检测并比较空腹血糖(FPG)、空腹胰岛素(FINS)、餐后1 h血糖(1 h PPG)、餐后1 h胰岛素(1 h INS)、餐后2 h血糖(2 h PPG)、餐后2 h胰岛素(2 h INS)、糖化血红蛋白(HbA1c)和体质量指数(BMI)。结果对照组仅26周和52周的1 h PPG低于基线(P<0.05),各个时间点BMI、HbA1c、FPG、FINS、1 h INS、2 h INS、2 h PPG水平比较,差异均无统计学意义(P>0.05)。试验组26、52周的1 h PPG、2 h PPG水平显著低于基线(P<0.05);52周的1 h INS水平较26周和基线升高(P<0.05),52周的2 h INS较26周和基线降低(P<0.05);试验组52周HbA1c、BMI和基线相比有显著改善(P<0.05);试验组在26周和52周的1 h PPG异常率和2 h PPG异常率均低于对照组(P<0.05)。结论八段锦能改善糖尿病高危人群餐后胰岛素分泌从而降低餐后血糖,尤其对1 h PPG、1 h INS改善更明显,值得在糖尿病高危人群中推广。
Objective To investigate the effects of Baduanjin on post-oral glucose tolerance test(OGTT)plasma glucose and insulin levels in individuals at high risk for diabetes.Methods A total of 200 individuals at high risk for diabetes who attended the outpatient and inpatient departments of Chongqing Nan′an District Hospital of Integrated Traditional Chinese and Western Medicine from March 2022 to May 2023 were randomized into two groups.Ultimately,92 participants in the control group and 91 in the intervention group were included in the analysis.The control group received diabetes dietary education plus a brisk-walking program,while the intervention group received the same regimen with the addition of Baduanjin.The intervention lasted 52 weeks.OGTT was conducted at baseline,26 weeks of intervention(26 weeks)and 52 weeks of intervention(52 weeks).Fasting plasma glucose(FPG),fasting insulin(FINS),1-hour postload plasma glucose(1 h PPG),1-hour insulin(1 h INS),2-hour postload plasma glucose(2 h PPG),2-hour insulin(2 h INS),glycated hemoglobin(HbA1c)and body mass index(BMI)were measured and compared.Results In the control group,only the 1 h PPG at 26 and 52 weeks was significantly lower than the baseline level(P<0.05).No statistically significant differences were observed in BMI,HbA1c,FPG,FINS,1 h INS,2 h INS,or 2 h PPG levels at any time point compared to baseline(P>0.05).In the intervention group,the 1 h PPG and 2 h PPG levels at 26 and 52 weeks were significantly lower than the baseline values(P<0.05).The 1 h INS level at 52 weeks was significantly higher than that at both 26 weeks and baseline(P<0.05),while the 2 h INS level at 52 weeks was significantly lower than that at both 26 weeks and baseline(P<0.05).Significant improvements in HbA1c and BMI were observed at 52 weeks compared with baseline in the intervention group(P<0.05).Furthermore,the abnormal rates of both 1 h PPG and 2 h PPG in the intervention group were significantly lower than those in the control group at both 26 and 52 weeks(P<0.05).Conclusion Baduanjin can improve postprandial insulin secretion and reduce postprandial blood glucose in the diabetes high-risk population,with more pronounced improvements observed in 1 h PPG and 1 h INS.Therefore,Baduanjin is recommended for promotion among individuals at high risk of diabetes.
作者
胡昌伦
张梅
张杨
杨刚毅
HU Changlun;ZHANG Mei;ZHANG Yang;YANG Gangyi(Department of Diabetes,Chongqing Nan′an District Hospital of Integrated Traditional Chinese and Western Medicine,Chongqing 400061,China;Department of Endocrinology,the Second Affiliated Hospital of Chongqing Medical University,Chongqing 400010,China)
出处
《检验医学与临床》
2025年第24期3427-3433,共7页
Laboratory Medicine and Clinic
基金
重庆市科卫联合项目(2022QNXM073)
重庆市卫生健康委员会中医药科研项目(2025WSJK167)
重庆市南岸区科卫联合项目(2024-34)。
关键词
八段锦
糖尿病
高危人群
口服葡萄糖耐量试验
血糖
胰岛素
糖化血红蛋白
Baduanjin
diabetes
high-risk population
oral glucose tolerance test
blood glucose
insulin
glycated hemoglobin
