摘要
Objective:To observe the effects of needle-embedding therapy combined with Western medication on sleep quality,emotional state,and prognosis in patients with depression accompanied by insomnia.Methods:A total of 50 patients with depression and insomnia treated between April 2019 and April 2020 were assigned to a medication group,and another 50 patients treated between May 2020 and May 2021 were assigned to a combination group.Both groups were treated with oral venlafaxine,while the combination group additionally received needle-embedding therapy.Traditional Chinese Medicine(TCM)symptom scores(excessive thinking and worrying,fatigue and weakness,and sleeplessness with irritability),sleep quality[Pittsburgh sleep quality index(PSQI)],and emotional state[17-item Hamilton depression scale(HAMD-17)]were compared between the two groups before treatment and after 2 weeks of treatment.Adverse reactions during treatment were recorded.Clinical efficacy was compared after treatment,and insomnia recurrence and readmission rates were observed 3 months after treatment.Results:After 2 weeks of treatment,TCM symptom scores,PSQI,and HAMD-17 scores in both groups were significantly lower than those before treatment(P<0.05),and all scores in the combination group were significantly lower than those in the medication group(P<0.05).The total effective rate in the combination group was significantly higher than that in the medication group(P<0.05).No significant adverse reactions occurred in either group during treatment.Within 3 months after treatment,the recurrence rate of insomnia and the readmission rate were significantly lower in the combination group than in the medication group(P<0.05).Conclusion:Needle-embedding therapy combined with oral venlafaxine is superior to venlafaxine alone in alleviating clinical symptoms and improving emotional states in patients with depression accompanied by insomnia,showing better short-term and long-term efficacy.
目的:观察埋针联合西药对抑郁症伴失眠患者睡眠质量、情绪状态及预后的影响。方法:观察埋针联合西药对抑郁症伴失眠患者睡眠质量、情绪状态及预后的影响。方法:纳入2019年4月至2020年4月就诊的50例抑郁症伴失眠患者为药物组;纳入2020年5月至2021年5月就诊的50例抑郁症伴失眠患者为联合组。两组均口服文拉法辛治疗,联合组加用埋针治疗。比较治疗前、治疗2周后两组患者中医症状评分(多思善虑、疲乏无力、失眠烦躁)、睡眠质量[匹兹堡睡眠质量指数(PSQI)]、情绪状态[汉密尔顿抑郁量表17项(HAMD-17)]。观察治疗期间不良反应。治疗后比较两组临床疗效;治疗后3个月观察比较两组失眠复发率和再入院率。结果:治疗2周后,两组患者的中医症状评分和PSQI、HAMD-17评分均较本组治疗前显著降低(P<0.05),联合组评分低于药物组(P<0.05)。联合组总有效率高于药物组(P<0.05)。治疗期间,两组均无发生明显不良反应。治疗后3个月内,联合组失眠复发率和再入院率均显著低于药物组(P<0.05)。结论:在口服文拉法辛治疗基础上加用埋针在减轻抑郁症伴失眠患者的临床症状,改善其情绪状态方面优于单独口服文拉法辛治疗,且近期及远期疗效更好。
基金
浙江省医药卫生科技计划项目,No.2020ky942.
