摘要
目的 探讨甲状腺乳头状癌(PTC)组织中高迁移率族蛋白A2(HMGA2)和具有血小板反应蛋白基序8的解整合素和金属蛋白酶(ADAMTS8)蛋白水平与临床病理参数及预后的关系。方法 收集2018年12月~2020年12月于本院行甲状腺切除术的128例PTC病人的癌组织及癌旁组织,收集其临床病理资料。采用免疫组织化学法检测组织中HMGA2和ADAMTS8蛋白表达水平,并分析其与临床病理参数的关系;采用Kaplan-Meier曲线分析HMGA2和ADAMTS8表达与PTC病人预后的关系;多因素Cox回归分析HMGA2和ADAMTS8表达对PTC病人预后的影响。结果 PTC组织和癌旁组织中HMGA2蛋白阳性表达率分别为64.84%、32.03%,ADAMTS8蛋白阳性表达率分别为61.72%、34.38%,两组比较差异有统计学意义(P<0.001);PTC组织中HMGA2和ADAMTS8蛋白表达水平与脉管侵犯、TNM分期、淋巴结转移、分化程度有关(P<0.05);HMGA2和ADAMTS8阳性表达病人3年生存率低于阴性表达病人,差异有统计学意义(χ^(2)=4.807、4.236,P<0.05);HMGA2(HR=1.752,95%CI=1.129~2.718)和ADAMTS8(HR=1.497,95%CI=1.113~2.013)阳性表达是PTC病人死亡的危险因素(P<0.05)。结论 PTC组织中HMGA2和ADAMTS8蛋白阳性表达率较高,二者表达水平与临床病理参数及预后有关。
Objective To investigate the relationship between the levels of high mobility group protein A2(HMGA2)and a disintegrin and metalloproteinase with thrombospondin motifs 8(ADAMTS8)in papillary thyroid carcinoma(PTC)tissue with clinical pathological parameters and prognosis.Methods Cancer and adjacent tissues of 128 PTC patients who underwent thyroidectomy in our hospital from December 2018 to December 2020 were collected,and clinical and pathological characteristics of the patients were collected.Immunohistochemical staining was applied to detect the expression levels of HMGA2 and ADAMTS8 proteins in tissues,and their relationship with clinical pathological parameters was analyzed.Kaplan-Meier curve was applied to analyze the relationship between HMGA2 and ADAMTS8 expression and the prognosis of PTC patients.Multivariate Cox regression was applied to analyze the impacts of HMGA2 and ADAMTS8 expression on the prognosis of PTC patients.Results The positive expression rates of HMGA2 protein in PTC tissues and adjacent tissues were 64.84%and 32.03%,respectively,and the positive expression rates of ADAMTS8 procoprotein were 61.72%and 34.38%,respectively.There was a statistically significant difference between the two groups(P<0.001).The expression levels of HMGA2 and ADAMTS8 proteins in PTC tissue were related to vascular invasion,TNM staging,lymph node metastasis,and differentiation degree(P<0.05).The 3-year survival rate of HMGA2 and ADAMTS8 positive expression patients was lower than that of negative expression patients(χ^(2)=4.807,4.236,P<0.05).Positive expression of HMGA2(HR=1.752,95%CI=1.129~2.718)and positive expression of ADAMTS8(HR=1.497,95%CI=1.113~2.013)were risk factors for mortality in PTC patients(P<0.05).Conclusion The positive expression rates of HMGA2 and ADAMTS8 proteins are relatively high in PTC tissues,and their expression levels are related to clinical pathological parameters and prognosis,which has certain clinical value.
作者
黄超
管小青
陈志峰
刘利
朱小朝
HUANG Chao;GUAN Xiaoqing;CHEN Zhifeng;LIU Li;ZHU Xiaochao(Department of Breast Surgery,Suqian First People's Hospital,Suqian 223800,China)
出处
《临床外科杂志》
2025年第11期1170-1174,共5页
Journal of Clinical Surgery
基金
2021年度徐州医科大学附属医院发展基金项目(XYFZ2021008)。
关键词
甲状腺乳头状癌
高迁移率族蛋白2
ADAMTS8
临床病理参数
预后
thyroid papillary carcinoma
high mobility group protein A2
a disintegrin and metalloproteinase with thrombospondin motifs 8
clinical pathological parameters
prognosis
