摘要
儿童颅内非生殖细胞瘤性生殖细胞肿瘤是一组具有高度异质性的罕见恶性肿瘤,包含未成熟畸胎瘤、胚胎癌、卵黄囊瘤、绒毛膜癌及混合性生殖细胞肿瘤等亚型。其治疗需整合手术、化疗与放疗等多学科手段,但在治疗顺序、手术时机及放化疗方案选择上存在显著争议。目前国际主流策略多推荐以铂类为基础的化疗联合术后放疗,而亚洲学者基于临床实践提出个体化手术优先策略,强调对于含畸胎瘤成分或≤3 cm的肿瘤应直接手术切除。
Pediatric intracranial non-germinoma Tous germ cell tumors(NGGCTs)are a group of rare,highly heterogeneous malignant tumors,encompassing subtypes such as immature teratoma,embryonal carcinoma,yolk sac tumor,choriocarcinoma,and mixed germ cell tumors.The management of NGGCTs requires the integration of multidisciplinary approaches including surgery,chemotherapy,and radiotherapy;however,significant controversies persist regarding treatment sequence,surgical timing,and the selection of chemoradiotherapy regimens.Currently,most international mainstream strategies recommend platinum-based chemotherapy combined with postoperative radiotherapy.In contrast,Asian researchers have proposed an individualized surgery-prioritized strategy based on clinical practice,emphasizing that tumors containing teratomatous components or measuring≤3 cm should undergo direct surgical resection.
作者
闫子寒
宫剑
YAN Zihan;GONG Jian(Department of Pediatric Neurosurgery,Beijing Tiantan Hospital,Capital Medical University,100070,China)
出处
《临床外科杂志》
2025年第11期1124-1128,共5页
Journal of Clinical Surgery
