摘要
目的探讨过氧苯甲酰凝胶联合异维A酸胶囊对中重度痤疮患者的治疗效果。方法选取2022年5月至2025年5月漯河市中心医院皮肤科收治的120例中重度痤疮患者进行回顾性研究,根据治疗方法差异分为对照组和观察组,各60例。对照组采用异维A酸胶囊治疗,观察组采用过氧苯甲酰凝胶和异维A酸胶囊治疗,均持续8周,比较两组患者的皮肤状态、皮肤屏障功能、痤疮评分。结果治疗后,观察组红斑、毛孔及紫质评分均低于对照组,差异有统计学意义(P<0.05);治疗后,观察组皮肤油脂含量、经皮水分丢失量均低于对照组,但皮肤含水量高于对照组,差异有统计学意义(P<0.05);治疗后,观察组卡迪夫痤疮伤残指数、痤疮综合分级系统评分均低于对照组,差异有统计学意义(P<0.05)。结论过氧苯甲酰凝胶联合异维A酸胶囊可在改善中重度痤疮患者皮肤炎症、调节皮肤油脂与水分平衡的同时,提升皮肤屏障功能,降低痤疮严重程度。
Objective To explore the therapeutic effects of benzoyl peroxide gel combined with isotretinoin capsules on patients with moderate to severe acne.Methods A retrospective study was conducted on 120 patients with moderate to severe acne admitted to the Department of Dermatology at Luohe Central Hospital from May 2022 to May 2025.Based on treatment differences,the patients were divided into a control group and an observation group,with 60 cases each.The control group received isotretinoin capsules,while the observation group was treated with both benzoyl peroxide gel and isotretinoin capsules,lasting 8 weeks.The skin conditions,skin barrier function,and acne scores of both groups were compared.Results After treatment,the observation group exhibited lower scores for erythema,pores,and purpura compared to the control group,with statistically significant differences(P<0.05).Additionally,the observation group showed lower sebum content and transepidermal water loss but higher skin hydration levels than the control group,with statistically significant differences(P<0.05).Post-treatment,the Cardiff Acne Disability Index and the Comprehensive Acne Grading System scores were also lower in the observation group than in the control group,with statistically significant differences(P<0.05).Conclusions The combination of benzoyl peroxide gel and isotretinoin capsules can improve skin inflammation,regulate oil and moisture balance,enhance skin barrier function,and reduce the severity of acne in patients with moderate to severe acne.
作者
任晶晶
刘纯卉
REN Jingjing;LIU Chunhui(Department of Dermatology,Luohe Central Hospital,Luohe 462000,Henan Province,China)
出处
《中国医疗美容》
2025年第11期37-41,共5页
China Medical Cosmetology
关键词
中重度痤疮
过氧苯甲酰凝胶
异维A酸胶囊
moderate to severe acne
Benzoyl peroxide gel
Isotretinoin capsule
