摘要
局部晚期宫颈癌(LACC)的标准治疗方案是以铂类为基础的同步放化疗,但仍有部分患者发生治疗抵抗、复发和转移。近年来,围绕LACC放化疗的优化策略研究取得了显著进展。当前,精准化革新是其放化疗优化的基石,调强放疗及影像引导放疗可精准提升肿瘤靶区剂量,同时显著减少对周围正常组织的损伤。此外,免疫治疗为改善高危患者预后带来希望,成为当前临床研究的热点。同时,针对特定分子通路的靶向药物探索也在进行中,旨在克服治疗抵抗。
The standard treatment regimen for locally advanced cervical cancer(LACC)is platinum-based concurrent chemoradiotherapy,but some patients still experience treatment resistance,recurrence and metastasis.In recent years,sig nificant progress has been made in the research on the optimization strategies of chemoradiotherapy for LACC.At present,precision innovation is the cornerstone of the optimization of radiotherapy and chemotherapy.Intensity-modulated radiotherapy and image-guided radiotherapy can precisely increase the dose to the tumor target area while significantly reducing damage to the surrounding normal tissues.Besides,immunotherapy brings hope for improving the prognosis of high-risk patients and has become a hot topic in current clinical research.Meanwhile,the exploration of targeted drugs for specific molecular path ways is also underway,aiming to overcome treatment resistance.
作者
黄婷
王静
HUANG Ting;WANG Jing(Gynecology Center,the First Affiliated Hospital of Xinjiang Medical University,Urumqi 830000,China;State Key Labo ratory of Pathogenesis,Prevention and Treatment of High Incidence Diseases in Central Asia/Xinjiang Key Laboratory of Medi cal Animal Model Research,Urumqi 830000,China)
出处
《医学综述》
2025年第21期2612-2617,共6页
Medical Recapitulate
基金
第三批“天山英才”医药卫生高层次人才项目(TSYC202401B016)
中央引导地方科技发展专项资金项目(ZYYD2023A09)。
关键词
局部晚期宫颈癌
根治性放化疗
调强放疗
图像引导放疗
免疫治疗
Locally advanced cervical cancer
Radical chemoradiotherapy
Intensity-modulated radiotherapy
Image guided radiotherapy
Immunotherapy
