摘要
目的分析视网膜色素变性(RP)患者眼部视盘参数、环视盘神经纤维层(CP-PNFL)厚度的变化情况。方法选取自2020年1月至2024年1月首都医科大学附属北京积水潭医院收治的80例RP患者(160眼)纳入RP组,另选取同期80例健康体检者(160眼)纳入健康组。采用光学相干断层扫描检测两组视盘参数及CP-PNFL厚度(全周及各象限)。比较RP组与健康组、RP患者初诊与1年后复诊[35例(70眼)]、不同病程(0~5年、5~10年、病程>10年)RP患者的视盘参数及CP-PNFL厚度。结果RP组视盘面积、视杯面积、视盘体积、C/D面积比、C/D水平直径比、C/D垂直直径比均高于健康组,差异均有统计学意义(P<0.05)。RP组全周、鼻侧、颞侧CP-PNFL厚度均高于健康组,差异均有统计学意义(P<0.05)。RP患者1年后复诊时视盘参数及CP-PNFL厚度与初诊比较,差异均无统计学意义(P>0.05)。不同病程患者视盘面积、视杯面积、视盘体积、C/D面积比、C/D水平直径比、C/D垂直直径比比较,差异均有统计学意义(P<0.05)。不同病程患者全周、鼻侧、颞侧CP-PNFL厚度比较,差异均有统计学意义(P<0.05)。结论RP患者存在特征性视盘参数及CP-PNFL厚度改变,且与病程进展密切相关。
Objective To analyze the changes in optic disc parameters and the thickness of circumpapillary retinal nerve fiber layer(CP-PNFL)in patients with retinitis pigmentosa(RP).Methods A total of 80 patients with RP(160 eyes)admitted to Beijing Jishuitan Hospital Affiliated to Capital Medical University from January 2020 to January 2024 were selected and included in the RP group.Another 80 healthy individuals(160 eyes)who underwent physical examinations during the same period were selected and included in the healthy group.Optical coherence tomography was used to detect the optic disc parameters of the two groups and the thickness of CP-PNFL(full circumference and each quadrant).The differences in the above indicators between the RP group and the healthy group,the initial diagnosis of RP patients and those who returned for follow-up one year later[35 cases(70 eyes)],and RP patients with different disease courses(0-5 years,5-10 years,course of disease>10 years)were compared.Results The optic disc area,optic cup area,optic disc volume,C/D area ratio,C/D horizontal diameter ratio,and C/D vertical diameter ratio in the RP group were all higher than those in the healthy group,and the differences were statistically significant(P<0.05).The thickness of CP-PNFL in the entire circumference,nasal side and temporal side of the RP group was higher than that of the healthy group,and the differences were statistically significant(P<0.05).When RP patients returned for follow-up one year later,there were no statistically significant differences in optic disc parameters and CP-PNFL thickness compared with those at the initial diagnosis(P>0.05).There were statistically significant differences in optic disc area,optic cup area,optic disc volume,C/D area ratio,C/D horizontal diameter ratio,and C/D vertical diameter ratio among patients with different disease courses(P<0.05).The comparison of CP-PNFL thickness throughout the week,nasal side and temporal side in patients with different disease courses showed statistically significant differences(P<0.05).Conclusion There are characteristic changes in optic disc parameters and CP-PNFL thickness in patients with RP,which are closely related to the progression of the disease.
作者
许静
刘爽
杨光
XU Jing;LIU Shuang;YANG Guang(Ophthalmology,Beijing Jishuitan Hospital,Capital Medical University,Beijing 102208,China)
出处
《临床军医杂志》
2025年第12期1233-1237,共5页
Clinical Journal of Medical Officers
基金
北京市属医院科研培育计划项目(PX2025012)。
关键词
视网膜色素变性
眼部视盘参数
环视盘神经纤维层厚度
Retinitis pigmentosa
Optic disc parameter
Thickness of circumpapillary retinal nerve fiber layer
