摘要
研究近年国内外主要睡眠剥夺模型,并探讨其在我国四大慢性病中的应用。大小鼠睡眠剥夺模型主要有改良多平台水环境法、轻度电击法、活动轮法、CPW范式法、睡眠剥夺仪法、轻柔刺激法、睡眠片段化等;斑马鱼睡眠剥夺模型主要有光照法、温和刺激法、生态水流法等;果蝇睡眠剥夺模型主要有机械刺激法、重复光刺激法、基因编辑法等。心脑血管疾病、癌症、慢性呼吸系统疾病、糖尿病四大慢病对人类健康的影响日益显著,了解睡眠剥夺模型在四大慢病的应用,为今后四大慢病的研究提供动物模型理论参考。
Research on major sleep deprivation models has developed in recent years,both domestically and internationally,together with exploration of their applications in China’s four major chronic diseases.The main sleep⁃deprivation models in rats and mice include the modified multiple platform water environment,mild electric shock,running wheel,coplanar waveguide paradigm,sleep deprivation instrument,gentle stimulation,and sleep fragmentation method.The sleep deprivation models for zebrafish mainly include the light exposure,mild stimulation,and ecological water flow method,while the main models for Drosophila include the mechanical stimulation,repetitive light stimulation,and gene editing method.The four major chronic diseases,cardiovascular and cerebrovascular diseases,cancer,chronic respiratory diseases,and diabetes,have an increasingly significant impact on human health.Understanding the application of sleep deprivation models in research related to these four major chronic diseases provides a theoretical reference for animal models in future studies of these conditions.
作者
胡斌
马巧琳
王凤云
陈家楠
宋甲奇
HU Bin;MA Qiaolin;WANG Fengyun;CHEN Jianan;SONG Jiaqi(Third Affiliated Hospital of Henan University of Traditional Chinese Medicine,Zhengzhou 450008,China;Henan University of Chinese Medicine,Zhengzhou 450046,China;Zhengzhou Hospital of Traditional Chinese Medicine,Zhengzhou 450007,China)
出处
《中国实验动物学报》
北大核心
2025年第11期1692-1700,共9页
Acta Laboratorium Animalis Scientia Sinica
基金
河南省中医药传承与创新人才工程(仲景工程)中医药拔尖人才项目(豫卫中医函[2021]15号)
河南省中医药科学院院属研究所2025年首批“揭榜挂帅”项目(豫卫中医药科教[2025]2号)。
关键词
睡眠剥夺
动物模型
四大慢病
sleep deprivation
animal model
four major chronic diseases
