摘要
目的探究替戈拉生(TPZ)联合高剂量阿莫西林(AMO)二联方案根除治疗幽门螺杆菌(Hp)的临床效果。方法选取2024年6月-12月上饶市广信区人民医院拟行Hp根除治疗的300例Hp感染患者,经随机数字表法分为观察组(n=142)与对照组(n=158)。观察组应用TPZ+高剂量AMO二联疗法,对照组应用含铋剂四联疗法,比较两组Hp根除率、症状积分、临床疗效与不良反应。结果观察组与对照组Hp根除率比较(ITT分析:85.92%vs.84.81%;PP分析:88.03%vs.87.34%),差异无统计学意义(P>0.05);两组治疗后症状积分(腹痛、腹胀、嗳气)均低于治疗前(P<0.05),但组间比较,差异无统计学意义(P>0.05);观察组与对照组治疗有效率比较(91.55%vs.91.14%),差异无统计学意义(P>0.05);观察组不良反应发生率低于对照组(7.75%vs.15.82%),差异有统计学意义(P<0.05)。结论TPZ联合高剂量AMO二联方案可有效改善Hp感染患者的临床症状,其Hp根除率、综合疗效与常规四联疗法相当,且表现出良好的用药安全性。
Objective To explore the clinical effect of tegoprazan(TPZ)combined with high-dose amoxicillin(AMO)dual therapy in the eradication of Helicobacter pylori(Hp).Methods From June to December 2024,300 patients with Hp infection who were scheduled to undergo Hp eradication in Shangrao Guangxin District People's Hospital were selected and divided into observation group(n=142)and control group(n=158)by random number table method.The observation group was treated with TPZ+high-dose AMO dual therapy,and the control group was treated with bismuth-containing quadruple therapy.The Hp eradication rate,symptom score,clinical efficacy and adverse reactions were compared between the two groups.Results There was no significant difference in Hp eradication rate between the observation group and the control group(ITT analysis:85.92%vs.84.81%;PP analysis:88.03%vs.87.34%)(P>0.05).The symptom scores(abdominal pain,abdominal distension,belching)of the two groups after treatment were lower than those before treatment(P<0.05),but there were no significant difference between the two groups(P>0.05).There was no significant difference in the effective rate between the observation group and the control group(91.55%vs.91.14%)(P>0.05).The incidence of adverse reactions in the observation group was lower than that in the control group(7.75%vs.15.82%),the difference was statistically significant(P<0.05).Conclusion TPZ combined with high-dose AMO dual therapy can effectively improve the clinical symptoms of patients with Hp infection,its Hp eradication rate and comprehensive efficacy are comparable to those of conventional quadruple therapy,and it shows good drug safety.
作者
陈淑平
徐铭
刘元东
CHEN Shuping;XU Ming;LIU Yuandong(Department of Gastroenterology,Shangrao Guangxin District People′s Hospital,Shangrao 334100,Jiangxi,China)
出处
《医学信息》
2025年第23期97-100,共4页
Journal of Medical Information
基金
江西省上饶市科技计划项目(编号:20241CZDX39)。
