摘要
目的 探讨血小板4项参数与急性淋巴细胞白血病(acute lymphoblastic leukemia,ALL)诊疗及预后的关系。方法选取2021年4月—2024年4月厦门市第三医院确诊为ALL的39例患者作为病例组,选取同时期39名健康体检者作为正常对照组。所有研究对象均采用迈瑞BC-6800plus全自动血细胞分析仪检测血小板计数(platelet count,PLT)、血小板平均体积(mean platelet volume,MPV)、血小板压积(plateletcrit,PCT)及血小板分布宽度(platelet distribution width,PDW)。将病例组的检测结果按照疾病进展情况分为化疗前期、骨髓抑制期、完全缓解期,分析正常对照组与病例组化疗前期、骨髓抑制期、完全缓解期的关系。结果 正常对照组的PLT为(224.31±55.23)×10^(9)/L,高于病例组化疗前期的(67.87±12.92)×10^(9)/L,高于病例组骨髓抑制期的(18.24±7.91)×10^(9)/L,差异有统计学意义(P<0.001)。正常对照组的PCT为(0.25±0.05)%,高于病例组化疗前期的(0.07±0.02)%,高于病例组骨髓抑制期的(0.02±0.01)%,差异有统计学意义(P<0.001)。正常对照组的PDW为(12.12±1.72)%,高于病例组骨髓抑制期的(9.20±1.05)%,差异有统计学意义(P<0.05)。结论 血小板4项参数可对ALL患者诊疗及预后提供有价值的依据。其中,PLT和PCT水平与治疗后ALL病情变化有明显的相关性,可以作为疾病缓解的客观依据。
Objective To explore the relationship between four parameters of platelets and the diagnosis,treatment and prognosis of acute lymphoblastic leukemia(ALL).Methods A total of 39 patients diagnosed with ALL in the Third Hospital of Xiamen from April 2021 to April 2024 were selected as the case group,and 39 healthy individuals undergoing physical examinations during the same period were selected as the normal control group.All research subjects were tested for platelet count(PLT),mean platelet volume(MPV),plateletcrit(PCT)and platelet distribution width(PDW)using the Mindray BC-6800plus.The test results of the case group were divided into the pre-chemotherapy period,the myelosuppression period and the complete remission period according to the disease progression,and the relationship between the normal control group and the case group in the pre-chemotherapy period,the myelosuppression period and the complete remission period was analyzed.Results The PLT of the normal control group was(224.31±55.23)×10^(9)/L,which was higher than(67.87±12.92)×10^(9)/L of the pre-chemotherapy period of the case group and higher than(18.24±7.91)×10^(9)/L of the myelosuppressive period of the case group,and the differences were statistically significant(P<0.001).The PCT of the normal control group was(0.25±0.05)%,which was higher than(0.07±0.02)%of the pre-chemotherapy period of the case group,and higher than(0.02±0.01)%of the myelosuppressive period of the case group,and the differences were statistically significant(P<0.001).The PDW of the normal control group was(12.12±1.72)%,which was higher than(9.20±1.05)%of the myelosuppressive period of the case group,and the difference was statistically significant(P<0.05).Conclusion The four parameters of platelets can provide valuable basis for the diagnosis,treatment and prognosis of ALL patients.Among them,the levels of PLT and PCT have a significant correlation with the changes in the condition of ALL after treatment,which can be used as an objective basis for disease remission.
作者
胡佳欣
杨清梅
HU Jiaxin;YANG Qingmei(Department of Clinical Medicine,Fujian Medical University,Fuzhou Fujian 350004,China;Department of Clinical Laboratory,the Third Hospital of Xiamen,Xiamen Fujian 361100,China)
出处
《中国卫生标准管理》
2025年第18期121-124,共4页
China Health Standard Management
基金
厦门市第三医院科研项目(3502Z20244ZD1349)。
关键词
急性淋巴细胞白血病
血小板参数
诊疗
预后
相关性
血液病学
acute lymphoblastic leukemia
platelet parameters
diagnosis and treatment
prognosis,correlation
hematology
