摘要
目的探讨异甘草酸镁注射液辅助保肝综合治疗对慢性乙型肝炎(CHB)肝硬化患者肝功能、肝纤维化的影响。方法将2020年1月至2024年1月于本院确诊的70例CHB肝硬化患者按随机数字表法分为常规组和联合组,各35例。常规组采用保肝综合治疗,联合组在常规组基础上联用异甘草酸镁注射液治疗。两组均持续治疗2周。比较两组治疗前、后的肝功能指标[白蛋白(ALB)、谷丙转氨酶(ALT)、谷草转氨酶(AST)及总胆红素(TBIL)]、肝纤维化指标[透明质酸(HA)、Ⅲ型前胶原N端肽(PC-Ⅲ)、层粘连蛋白(LN)和Ⅳ型胶原(Ⅳ-C)]及生活质量核心量表(QLQ-C30)评分;比较两组的临床症状(恶心呕吐、食欲不振等)恢复时间及不良反应发生情况。结果治疗后,联合组的ALB水平高于常规组,ALT、AST、TBIL、HA、PC-Ⅲ、LN、Ⅳ-C水平低于常规组(P<0.05)。联合组的肝区不适、恶心呕吐、乏力、食欲不振恢复时间均短于常规组(P<0.05)。治疗后,两组的躯体功能、角色功能、情绪功能评分均升高,且联合组高于常规组(P<0.05)。两组的不良反应总发生率无显著差异(P>0.05)。结论异甘草酸镁注射液辅助保肝综合治疗可改善CHB肝硬化患者的肝功能和肝纤维化,值得临床推广应用。
Objective To investigate the effects of magnesium isoglycyrrhizinate injection combined with comprehensive liver protection therapy on liver function and liver fibrosis in patients with chronic hepatitis B(CHB)liver cirrhosis.Methods A total of 70 patients with CHB liver cirrhosis diagnosed in our hospital from January 2020 to January 2024 were divided into conventional group and combined group according to random number table method,with 35 cases in each group.The conventional group was treated with comprehensive treatment of liver protection,and the combined group was treated with magnesium isoglycyrrhizinate injection on the basis of the conventional group.Both groups were treated for 2 weeks.The liver function indexes[albumin(ALB),alanine aminotransferase(ALT),glutamic oxaloacetic transaminase(AST)and total bilirubin(TBIL)],liver fibrosis indexes[hyaluronic acid(HA),typeⅢprocollagen N-terminal peptide(PC-Ⅲ),laminin(LN)and typeⅣcollagen(Ⅳ-C)]and Quality of Life Questionnaire-Core 30(QLQ-C30)score were compared between the two groups before and after treatment;the recovery time of clinical symptoms(nausea and vomiting,loss of appetite,etc.)and the occurrence of adverse reactions were compared between the two groups.Results After treatment,the ALB level in the combined group was higher than that in the conventional group,and the levels of ALT,AST,TBIL,HA,PC-Ⅲ,LN andⅣ-C were lower than those in the conventional group(P<0.05).The recovery time of liver discomfort,nausea and vomiting,fatigue and loss of appetite in the combined group were shorter than those in the conventional group(P<0.05).After treatment,the scores of physical function,role function and emotional function in the two groups increased,and those in the combined group were higher than the conventional group(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Magnesium isoglycyrrhizinate injection combined with comprehensive treatment of liver protection therapy can improve liver function and liver fibrosis in patients with CHB liver cirrhosis, which is worthy of clinical application.
作者
戴如
张伟
陈杰妮
熊艳
DAI Ru;ZHANG Wei;CHEN Jieni;XIONG Yan(Infectious Diseases Department,Wuxue No.1 People's Hospital,Wuxue 435400,China)
出处
《临床医学研究与实践》
2025年第36期71-74,共4页
Clinical Research and Practice
关键词
异甘草酸镁
慢性乙型肝炎
肝硬化
肝功能
肝纤维化
magnesium isoglycyrrhizinate
chronic hepatitis B
liver cirrhosis
liver function
liver fibrosis
