摘要
目的:观察温经通络散联合前列地尔对糖尿病足(DF)患者创面微血管密度及间歇性跛行的影响。方法:回顾性筛选2022年2月—2024年2月金华市中医医院收治的80例DF患者,根据治疗方法不同分为前列地尔组39例和联合组41例。前列地尔组给予前列地尔进行治疗,联合组给予温经通络散联合前列地尔治疗。比较2组临床疗效、症状评分、血糖指标[空腹血糖(FBG)、餐后2 h血糖(P2hBG)、糖化血红蛋白(HbA1c)]水平、创面微血管密度及足背动脉血流速度、血清炎症因子指标[超敏C-反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)]水平。结果:治疗后,联合组总有效率为95.12%(39/41),前列地尔组为76.92%(30/39),2组比较,差异有统计学意义(P<0.05)。治疗后,2组间歇性跛行、疼痛感、麻木感、冷沉重感等症状评分均较治疗前降低(P<0.05),且联合组各项评分均低于前列地尔组(P<0.05)。治疗后,2组FBG、P2hBG及HbA1c水平均较治疗前降低(P<0.05),且联合组3项指标水平均低于前列地尔组(P<0.05)。治疗后,2组创面微血管密度及足背动脉血流速度均较治疗前升高(P<0.05),且联合组上述2项指标水平均高于前列地尔组(P<0.05)。治疗后,2组hs-CRP、TNF-α、IL-6水平均较治疗前降低(P<0.05),且联合组3项指标水平均低于前列地尔组(P<0.05)。结论:采用温经通络散联合前列地尔治疗DF患者疗效显著,可提高创面微血管密度,促进足部血液循环,减轻机体炎症反应,改善间歇性跛行症状。
Objective:To observe the effects of Wenjing Tongluo Powder combined with Alprostadil on wound microvessel density and intermittent claudication in patients with diabetic foot(DF).Methods:A total of 80 DF patients admitted to Jinhua Hospital of Traditional Chinese Medicine from February 2022 to February 2024 were retrospectively selected and divided into the Alprostadil group(39 cases)and the combination group(41 cases)based on clinical treatment methods.The Alprostadil group received Alprostadil alone,while the combination group received Wenjing Tongluo Powder combined with Alprostadil.The clinical efficacy,symptom scores,blood glucose indicator levels[fasting blood glucose(FBG),2-hour postprandial blood glucose(P2hBG),glycated hemoglobin(HbA1c)],wound microvessel density and dorsalis pedis artery blood flow velocity,and levels of serum inflammatory factor indicators[high-sensitivity C-reactive protein(hs-CRP),tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)]were compared between the two groups.Results:After treatment,the total effective rate was 95.12%(39/41)in the combination group and 76.92%(30/39)in the Alprostadil group,with significant difference between the two groups(P<0.05).After treatment,the symptom scores for intermittent claudication,sensation of pain,sensation of numbness,and sensation of cold and heaviness decreased in both groups compared to before treatment(P<0.05),and the above scores in the combination group were lower than those in the Alprostadil group(P<0.05).After treatment,the levels of FBG,P2hBG,and HbA1c decreased in both groups compared to before treatment(P<0.05),and the levels of the above three indicators in the combination group were lower than those in the Alprostadil group(P<0.05).After treatment,wound microvessel density and dorsalis pedis artery blood flow velocity increased in both groups compared to before treatment(P<0.05),and the levels of the above two indicators in the combination group were higher than those in the Alprostadil group(P<0.05).After treatment,the levels of hs-CRP,TNF-α,and IL-6 decreased in both groups compared to before treatment(P<0.05),and the levels of the above three indicators in the combination group were lower than those in the Alprostadil group(P<0.05).Conclusion:The combination of Wenjing Tongluo Powder and Alprostadil has significant therapeutic efficacy in the treatment of DF patients.It can increase the wound microvessel density,promote the foot blood circulation,and reduce the body's inflammatory responses,improve the symptoms of intermittent claudication.
作者
潘金梅
黄珊
徐惠惠
黄兆一
PAN Jinmei;HUANG Shan;XU Huihui;HUANG Zhaoyi(Endocrinology Department,Jinhua TCM Hospital Affiliated to Zhejiang Chinese Medical University,Jinhua Zhejiang 321000,China)
出处
《新中医》
2025年第24期54-58,共5页
New Chinese Medicine
基金
浙江省中医药科学研究基金项目(2021ZB323)。
关键词
糖尿病足
间歇性跛行
温经通络散
前列地尔
创面微血管密度
Diabetic foot
Intermittent claudication
Wenjing Tongluo Powder
Alprostadil
Wound microvessel density
