摘要
目的:系统评价类风湿关节炎患者骨质疏松症发生率及其影响因素。方法:计算机检索The Cochrane Library、PubMed、Web Of Science、EMbase、Sinomed、中国知网、万方、维普等数据库中有关类风湿关节炎患者骨质疏松症的观察性研究,检索时间从建库至2024年11月。筛选文献、提取数据、评价文献质量,用STATA 18软件进行分析。结果:合计纳入32篇文献,共有7080例研究对象。Meta分析结果显示,类风湿关节炎患者的骨质疏松症发生率为40.4%[95%CI(36.4%~44.5%)],年龄、病程、性别、身体质量指数(Body Mass Index,BMI)、Sharp评分、红细胞沉降率(Erythrocyte Sedimentation Rate,ESR)等因素均是其影响因素。结论:当前证据显示,类风湿关节炎患者骨质疏松症发生率较高,且受多种因素影响。但受纳入研究数量和质量的限制,上述结论仍需更多高质量研究予以验证。
Objective:To systematically evaluate the incidence rate and influencing factors of osteoporosis in rheumatoid arthritis patients.Methods:Databases such as the Cochrane Library,PubMed,Web Of Science,EMbase,Sinomed,CNKI,Wanfang Data,and VIP were searched by computer to screen out observational studies on osteoporosis in rheumatoid arthritis patients.The search time was from the establishment of each database to November 2024.After screening the literatures,extracting the data,and evaluating the quality of the literatures,STATA 18 software was used for relevant analysis.Results:A total of 32 papers were included,involving 7080 research subjects.Results of the Meta-analysis showed that the incidence rate of osteoporosis in rheumatoid arthritis patients was 40.4%[95%CI(36.4%-44.5%)],and factors such as age,disease course,female gender,BMI,Sharp score,and ESR were all the influencing factors.Conclusion:The current evidence shows that the incidence rate of osteoporosis in rheumatoid arthritis patients is relatively high and is affected by multiple factors.However,due to the limitations of the number and quality of the included studies,the above conclusions still need to be verified by more high-quality studies.
出处
《中医临床研究》
2025年第28期141-148,共8页
Clinical Journal Of Chinese Medicine
