摘要
目的:比较辅助生殖技术(ART)与自然受孕的单胎妊娠孕妇妊娠期并发症、不良妊娠结局及可溶性fms样酪氨酸激酶-1(sFlt-1)/胎盘生长因子(PLGF)的差异。方法:前瞻性纳入通过ART获得临床单胎妊娠的547例孕妇作为ART组(n=547),在基线均衡性原则下以1∶2比例匹配同期于本院产科建卡的1094例自然单胎受孕孕妇纳入对照组(n=1094)。比较两组孕妇妊娠期并发症、妊娠结局及sFlt-1/PLGF比值。结果:ART组孕妇妊娠期糖尿病、妊娠期高血压、子痫前期、产后出血及胎儿窘迫发生率高于对照组(P<0.05)。ART组孕妇剖宫产、胎儿生长受限、早产及低出生体质量儿发生率高于对照组(P<0.05)。ART组孕妇血清PLGF水平低于对照组,sFlt-1水平及sFlt-1/PLGF比值高于对照组(P<0.05)。结论:ART助孕的单胎妊娠孕妇,其妊娠期并发症、不良妊娠结局风险仍高于自然受孕,需加强对该类孕妇孕前-产前-产后的全程管理以改善母婴结局。
Objective:To compare the differences in gestational complications,adverse pregnancy outcomes,and soluble fms-like tyrosine kinase-1(sFlt-1)/placental growth factor(PLGF)levels between singleton pregnancies conceived via assisted reproductive technology(ART)and natural conception.Methods:This prospective study enrolled 547 pregnant women with clinical singleton pregnancies achieved through ART as the ART group(n=547).Based on baseline balance principles,1,094 naturally conceived singleton pregnant women registered at our hospital s obstetrics department during the same period were matched at a 1∶2 ratio as the control group(n=1,094).The gestational complications,pregnancy outcomes,and the sFlt-1/PLGF ratio were compared between the two groups.Results:The incidence of gestational diabetes mellitus,gestational hypertension,preeclampsia,postpartum hemorrhage,and fetal distress in the ART group were higher than those in the control group(P<0.05).The rates of cesarean section,fetal growth restriction,preterm birth,and low birth weight were higher in the ART group(P<0.05).Serum PLGF levels were lower,while sFlt-1 levels and the sFlt-1/PLGF ratio were higher in the ART group compared to the control group(P<0.05).Conclusion:Singleton pregnancies conceived through ART demonstrate higher risks of gestational complications and adverse outcomes compared to naturally conceived pregnancies,necessitating tailored management spanning pre-conception,prenatal,and postnatal stages to optimize maternal and neonatal outcomes.
作者
杨芳平
郑剑兰
刘景兮
YANG Fang-ping;ZHENG Jian-lan;LIU Jing-xi(Department of Obstetrics and Gynecology,the 73rd Group Army Hospital of PLA,Chenggong Hospital Affiliated with Xiamen University,Xiamen 361001,Fujian,China)
出处
《川北医学院学报》
2025年第12期1574-1577,共4页
Journal of North Sichuan Medical College
基金
福建省厦门市科技计划项目(3502Z20184066)。
关键词
辅助生殖技术
单胎妊娠
妊娠期并发症
不良妊娠结局
可溶性fms样酪氨酸激酶-1
胎盘生长因子
Assisted reproductive technology
Singleton pregnancy
Gestational complications
Adverse pregnancy outcome
Soluble fms-like tyrosine kinase-1
Placental growth factor
