摘要
目的探究脐针联合维生素E、促排卵药物对多囊卵巢综合征不孕症患者的治疗效果,以及对氧化应激指标的影响。方法140例多囊卵巢综合征不孕症患者,随机分为试验组与对照组,各70例。试验组患者使用脐针联合维生素E、促排卵药物治疗,对照组患者单纯使用维生素E、促排卵药物治疗。对比两组排卵后1周孕酮(P)水平与超声指标,治疗效果,氧化应激指标[超氧化物歧化酶(SOD)、谷胱甘肽还原酶(GSH)、卵泡刺激素(FSH)]。结果试验组排卵后1周P水平(1.58±0.31)nmol/L高于对照组的(1.36±0.24)nmol/L,优势卵泡大小(20.25±2.22)mm、子宫内膜厚度(9.58±0.42)mm大于对照组的(17.53±2.25)、(8.36±0.21)mm,成熟卵泡数量(1.64±0.36)个多于对照组的(1.08±0.21)个(P<0.05)。试验组治疗总有效率100.00%高于对照组的92.86%(P<0.05)。治疗后,试验组SOD(200.52±12.51)U/ml、GSH(48.63±3.33)U/L、FSH(6.32±0.15)mIU/ml高于对照组的(186.46±12.33)U/ml、(42.16±3.24)U/L、(5.42±0.28)mIU/ml(P<0.05)。结论脐针联合维生素E、促排卵药物对多囊卵巢综合征不孕症患者进行治疗,能促进患者排卵后1周孕激素水平的恢复,同时促进优势卵泡大小、成熟卵泡生长及子宫内膜厚度的恢复,可实现理想治疗效果,达到对氧化应激状况的改善管理作用,可广泛应用于临床治疗中。
Objective To explore the therapeutic effect of umbilical acupuncture combined with vitamin E and ovulation-inducing drugs on infertile patients with polycystic ovary syndrome,as well as its influence on oxidative stress index.Methods A total of 140 infertile patients with polycystic ovary syndrome were randomly divided into the experimental group and the control group,each with 70 cases.Patients in the experimental group were treated with umbilical acupuncture combined with vitamin E and ovulation-inducing drugs,while patients in the control group were treated with vitamin E and ovulation-inducing drugs alone.The progesterone(P)levels and ultrasound indicators 1 week after ovulation,therapeutic effects,and oxidative stress indexes[superoxide dismutase(SOD),glutathione reductase(GSH),follicle-stimulating hormone(FSH)]were compared between the two groups.Results 1 week after ovulation,the experimental group had a higher P level(1.58±0.31)nmol/L than the control group's(1.36±0.24)nmol/L;the dominant follicle size in the experimental group was(20.25±2.22)mm and the endometrial thickness(9.58±0.42)mm,which were greater than those in the control group[(17.53±2.25)and(8.36±0.21)mm];the number of mature follicles(1.64±0.36)was more than the control group's(1.08±0.21)(P<0.05).The total effective rate of treatment in the experimental group was 100.00%,which was higher than the control group's 92.86%(P<0.05).After treatment,the experimental group had SOD of(200.52±12.51)U/ml,GSH of(48.63±3.33)U/L,and FSH of(6.32±0.15)mIU/ml,which were higher than those in the control group[(186.46±12.33)U/ml,(42.16±3.24)U/L,and(5.42±0.28)mIU/ml](P<0.05).Conclusion Combined treatment with umbilical acupuncture,vitamin E,and ovulation-inducing drugs for infertile patients with polycystic ovary syndrome can promote the recovery of progesterone levels 1 week after ovulation.It simultaneously enhances the dominant follicle size,mature follicle growth,and endometrial thickness restoration,achieving optimal therapeutic outcomes.This approach effectively manages oxidative stress conditions,and can be widely applied in clinical practice.
作者
曾小连
阙彬福
陈绍菲
林久茂
ZENG Xiao-lian;QUE Bin-fu;CHEN Shao-fei(College of Integrated Traditional Chinese and Western Medicine,Fujian University of Traditional Chinese Medicine,Institute of Integrated Traditional Chinese and Western Medicine,Fuzhou 350122,China)
出处
《中国现代药物应用》
2026年第3期32-36,共5页
Chinese Journal of Modern Drug Application
关键词
脐针
维生素E
促排卵药物
多囊卵巢综合征
不孕症
Umbilical acupuncture
Vitamin E
Ovulation-inducing drugs
Polycystic ovary syndrome
Infertility
