摘要
目的:探究哌拉西林钠他唑巴坦(PIP-TAZ)联合左氧氟沙星(Lfx)对慢性阻塞性肺疾病(COPD)合并肺炎患者的治疗效果。方法:选取2023年1月至2024年9月在徐州中西医结合医院就诊的92例COPD合并肺部感染患者。根据随机数字表法分为两组。对照组(46例)用左氧氟沙星治疗;观察组(46例)用PIP-TAZ联合Lfx治疗。对比两组临床疗效。结果:观察组总有效率高于对照组(P<0.05),治疗后炎症因子水平低于对照组(P<0.05);两组不良反应总发生率比较差异不显著(P>0.05)。结论:PIP-TAZ联合Lfx治疗COPD合并肺炎的疗效显著,安全性较高,可降低炎症因子水平,具有较高的临床推广价值。
Objective:To investigate the therapeutic effect of piperacillin sodium tazobactam(PIP-TAZ)combined with levofloxacin(Lfx)on patients with chronic obstructive pulmonary disease(COPD)complicated with pneumonia.Method:92 patients with COPD complicated with pulmonary infection who received treatment at Xuzhou Integrated Traditional Chinese and Western Medicine Hospital from January 2023 to September 2024 were selected.Divide into two groups according to the random number table method.46 cases in the control group were treated with levofloxacin;46 cases in the observation group were treated with PIP-TAZ combined with Lfx.Compare the clinical efficacy of the two groups.Result:The total effective rate of the observation group was higher than that of the control group,and the levels of inflammatory factors after treatment were lower than those of the control group(P<0.05);The difference in the incidence of adverse reactions between the two groups was not significant(P>0.05).Conclusion:PIP-TAZ combined with Lfx has significant efficacy,high safety,and can reduce the level of inflammatory factors in the treatment of COPD complicated with pneumonia.It has high clinical promotion value.
作者
郭敏
GUO Min(Department of Respiratory and Critical Care Medicine,Xuzhou Hospital of Integrated Traditional Chinese and Western Medicine(Xuzhou Mining Hospital),Xuzhou 221006,China)
出处
《延边大学医学学报》
2025年第12期72-74,共3页
Journal of Medical Science Yanbian University
关键词
慢性阻塞性肺疾病
肺炎
哌拉西林钠他唑巴坦
左氧氟沙星
炎症因子
Chronic obstructive pulmonary disease
Pneumonia
Piperacillin sodium and tazobactam
Levofloxacin
Inflammatory factors
