摘要
目的:基于CiteSpace和VOSviewer对中医药治疗心肌缺血再灌注损伤的研究文献进行分析,以探索其研究现状、热点和趋势,为临床应用提供参考。方法:计算机检索中国知网、万方数据库、维普数据库及中国生物医学文献数据库自建库至2023年4月收录的中医药治疗心肌缺血再灌注损伤研究文献,对发文量、作者、机构、关键词等信息进行分析。结果:经筛选,共纳入1249篇中医药治疗心肌缺血再灌注损伤研究文献,年发文量呈现出由波动到平稳的态势,表明这一领域的研究已经趋于稳定。在这些研究中,涌现出一些高发文量机构,如黑龙江中医药大学、中国中医科学院西苑医院、湖南中医药大学、山东中医药大学、南京中医药大学等;发文较多的作者有李冀、刘建勋、周苏宁、张文高、黄政德等。高频关键词包括“心肌缺血再灌注损伤”“中医药”“大鼠”“细胞凋亡”“作用机制”等,并生成了33个聚类标签和25个突现词。结论:目前中医药治疗心肌缺血再灌注损伤相关研究不断发展,已形成稳定的研究团队,但机构间合作多以大学及其附属医院为主,尚未形成大规模、跨区域的作者和机构合作网络。研究热点主要集中在疾病机制、中医药治疗和复方以及单味中药的提取等方面。尽管已经开展一些临床研究,但关于临床实际有效的中药复方的研究缺乏深度和广度。大多数研究仍停留在某些常见相关指标的重复观测上,而对于具体反应机制的深入研究较少。未来应当加强临床研究和复方制剂综合研究,以推动这一领域的深入发展。
Objective:The literature on treating myocardial ischemia-reperfusion injury in traditional Chinese medicine was analyzed by the CiteSpace and VOSviewer to explore the research status,research hot,and trends,so as to provide more reference for clinical application.Methods:The literature on treating myocardial ischemia reperfusion-injury in traditional Chinese medicine were retrieved from CNKI,Wanfang Database,VIP database and China Biomedical Literature Database from initial stages of databases to April 2023,and the number of publications,authors,institutions,and keywords were analyzed.Results:After screening,1249 research articles on treating myocardial ischemia-reperfusion injury in traditional Chinese medicine were included totally.The annual publication number indicated a trend from fluctuation to stability,suggesting that the research in this field was reaching a stable phase.Institutions with high publication numbers included Heilongjiang University of Chinese Medicine,Xiyuan Hospital of China Academy of Chinese Medical Sciences,Hunan University of Chinese Medicine,Shandong University of Traditional Chinese Medicine,Nanjing University of Chinese Medicine,etc.Prolific authors included LI Ji,LIU Jianxun,ZHOU Suning,ZHANG Wen’gao,and HUANG Zhengde.High-frequency keywords were myocardial ischemia-reperfusion injury,traditional Chinese medicine,rats,cell apoptosis,action mechanism,etc.A total of 33 cluster labels and 25 emergent words were obtained.Conclusions:Currently,the research related to treating myocardial ischemia-reperfusion injury in traditional Chinese medicine is constantly evolving,and stable research teams has been formed.However,inter-institutional collaborations were mainly confined to universities and their affiliated hospitals,and a large-scale,cross-regional author or institution cooperation network had not yet been formed.The research hotspots were mainly the pathogenesis mechanism,traditional Chinese medicine treatment,and the extraction of compound prescriptions and single Chinese medicinal materials.Although some clinical studies have been initiated,there is a lack of more in-depth and comprehensive research on clinically effective traditional Chinese medicine compound prescriptions.Most studies still remain at the level of repetitive observations on certain common related indicators,while in-depth research on specific underlying mechanisms is relatively scarce.In the future,efforts should concentrate on enhancing clinical research and compound formulation comprehensive studies to promote the in-depth development of this field.
出处
《中医临床研究》
2025年第26期56-65,共10页
Clinical Journal Of Chinese Medicine
基金
国家自然科学基金项目(81803936)
河北省自然科学基金项目(H2022209031)
河北省中医药管理局科研计划项目(2024354)。
关键词
中医药
心肌缺血再灌注损伤
可视化
Traditional Chinese medicine
Myocardial ischemia-reperfusion injury
Visualization
