摘要
目的针对老年2型糖尿病(type 2 diabetes mellitus,T2DM)患者群体,探析可能诱发其出现轻度认知功能障碍的风险因素。方法回顾性选取2021年6月—2023年6月西宁市第一人民医院收治的180例老年T2DM住院患者的临床资料,按照是否存在轻度认知功能障碍分为存在轻度障碍组(n=85)和不存在轻度障碍组(n=95)。通过多因素二元Logistic回归分析探讨诱发此类患者群体出现轻度认知功能障碍的影响因素。结果存在轻度障碍组患者的同型半胱氨酸、肌酐、尿酸、甘油三酯水平均高于不存在轻度障碍组,叶酸水平低于不存在轻度障碍组,差异均有统计学意义(P均<0.05)。多因素二元Logistic回归分析显示,同型半胱氨酸>17.56μmol/L、肌酐>90.42μmol/L、尿酸>336 mg/d、甘油三酯>1.51μmol/L均为造成T2DM患者发生轻度认知功能障碍的危险因素,叶酸≥9.12 ng/mL为T2DM患者轻度认知功能障碍的保护因素(P均<0.05)。结论同型半胱氨酸、肌酐、尿酸、甘油三酯、叶酸水平均为老年T2DM患者发生轻度认知功能障碍的影响因素,临床中应针对上述影响因素制订有针对性的干预对策,以减少轻度认知功能障碍的发生。
Objective To explore the risk factors that may induce mild cognitive impairment in elderly patients with type 2 diabetes mellitus(T2DM).Methods The clinical data of 180 elderly patients with T2DM admitted to the Xining First People's Hospital from June 2021 to June 2023 were retrospectively selected.According to the presence or absence of mild cognitive impairment,the patients were divided into mild impairment group(n=85)and non-mild impairment group(n=95).Through single factor analysis and multivariate binary Logistic analysis,the influencing factors of mild cognitive impairment in such patients were discussed.Results The levels of homocysteine,creatinine,uric acid and triglyceride in the mild impairment group were higher than those in the non-mild disorder group,and the folic acid level was lower than that in the non-mild impairment group,the differences were statistically significant(all P<0.05).Multivariate binary Logistic analysis showed that homocysteine>17.56μmol/L,creatinine>90.42μmol/L,uric acid>336 mg/d,triglyceride>1.51μmol/L were risk factors for mild cognitive impairment in T2DM patients,folic acid≥9.12 ng/mL was protective factor for mild cognitive impairment in T2DM patients(all P<0.05).Conclusion The levels of homocysteine,creatinine,uric acid,triglyceride and folic acid are influence factors for mild cognitive impairment in elderly patients with T2DM.Targeted intervention measures should be formulated according to the above influencing factors in clinical practice to reduce the occurrence of mild cognitive impairment.
作者
李冬萍
包小燕
田立
山永仪
LI Dongping;BAO Xiaoyan;TIAN Li;SHAN Yongyi(Department of Endocrine and Metabolic Diseases,Xining First People's Hospital,Xining 810000,Qinghai,China)
出处
《糖尿病新世界》
2025年第21期8-12,共5页
Diabetes New World
基金
西宁市科技计划项目(民生科技专项)(2021-M-29)。
关键词
老年2型糖尿病
轻度认知功能障碍
影响因素
Elderly type 2 diabetes mellitus
Mild cognitive impairment
Influencing factor
