摘要
目的探讨通督灸联合穴位贴敷干预对多发性骨髓瘤(MM)癌性疼痛患者痛感与生活质量的影响。方法选取2022年6月—2024年6月于医院接受治疗的80例MM癌性疼痛患者为研究对象,按照随机数字表法分为对照组和观察组,各40例。两组患者均给予常规护理干预治疗,对照组给予WHO三阶梯止痛法,观察组在对照组基础上给予通督灸联合穴位贴敷治疗,两组均连续治疗4周。比较两组患者治疗有效率、中医证候积分、疼痛数字评分法(NRS)评分、卡氏评分(KPS)、血清疼痛介质[前列腺素E2(PGE2)、P物质(SP)、5-羟色胺(5-HT)]水平、癌症患者生活质量核心问卷(EORTC QLQ-C30)评分以及不良反应发生率。结果干预后,观察组患者治疗有效率高于对照组,差异有统计学意义(P<0.05)。干预后,观察组患者的中医证候积分、NRS评分、EORTC QLQ-C30的症状评分、SP、5-HT、PGE2水平均低于对照组,差异有统计学意义(P<0.05),KPS评分、EORTC QLQ-C30的功能评分高于对照组,差异有统计学意义(P<0.05)。两组患者不良反应发生率比较差异无统计学意义(P>0.05)。结论通督灸与穴位贴敷干预对MM癌性疼痛患者的疗效显著,能够有效缓解其中医证候状况,减轻痛感,改善血清疼痛介质水平和提升生活质量水平,且治疗安全性较好。
Objective To investigate the effects of combined Tongdu moxibustion and acupoint plaster application on pain perception and quality of life in patients with cancer pain due to multiple myeloma(MM).Methods Eighty patients with cancer pain due to MM treated at hospital between June 2022 and June 2024 were enrolled.They were randomly assigned to a control group and an observation group(n=40)by a random number table.Both groups received routine nursing interventions.The control group underwent WHO three-step analgesic ladder approach,the observation group additionally received Tongdu moxibustion combined with acupoint plaster application.Treatment was administered continuously for 4 weeks in both groups.The following parameters were compared between groups:treatment efficacy rate,Traditional Chinese Medicine(TCM)syndrome scores,Numerical Rating Scale(NRS)scores,Karnofsky Performance Status(KPS)score,serum levels of pain mediators[prostaglandin E2(PGE2),substance P(SP),serotonin(5-HT)],European Organisation for Research and Treatment of Cancer Quality of Life Core Questionnaire(EORTC QLQ-C30)scores,and incidence of adverse reactions.Results After intervention,the treatment response rate in the observation group was significantly higher than that in the control group(P<0.05).After intervention,the observation group exhibited significantly lower scores for TCM syndrome,NRS,EORTC QLQ-C30 symptom domains,and serum levels of SP,5-HT,and PGE2 compared to the control group(P<0.05).while KPS scores and EORTC QLQ-C30 functional scores were higher than those in the control group,with statistically significant differences(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Tongdu moxibustion combined with acupoint plaster application demonstrated significant efficacy in managing cancer pain among multiple myeloma patients.This intervention effectively alleviated traditional Chinese medicine syndromes,reduced pain intensity,improved serum pain mediator levels,and enhanced quality of life,while exhibiting favourable safety profiles.
作者
李彦珊
张玉
李丽
胡海珍
李国英
熊苏云
邹明玥
刘淑群
冷瑞芳
周静然
LI Yanshan;ZHANG Yu;LI Li;HU Haizhen;LI Guoying;XIONG Suyun;ZOU Mingyue;LIU Shuqun;LENG Ruifang;ZHOU Jingran(The Second Affiliated Hospital of Nanchang University,Nanchang 330000,China)
出处
《护理实践与研究》
2025年第12期1782-1787,共6页
Nursing Practice and Research
基金
江西省中医药管理局科技计划(编号:2024B0681)。
关键词
通督灸
穴位贴敷
多发性骨髓瘤
癌性疼痛
生活质量
Tongdu moxibustion
Acupoint plaster application
Multiple myeloma
Cancer pain
Quality of life
