摘要
The symptoms of allergic airway disease are impacted by the interplay of gut microbiota,which may be modulated by probiotics.This study aimed to investigate the potential anti-inflammatory effects of three lactic acid bacteria(LAB)on allergic asthma through modulation of the gut microbiota.Ovalbumin(OVA)-induced asthmatic mice were treated with three LAB strains,and their gut microbiota profiles were analyzed using 16S rRNA sequencing.Fecal microbiota transplantation(FMT)from mice fed with Lactobacillus rhamnosus RL-H3-005 was administered to OVA-induced asthmatic mice.The results demonstrated that RL-H3-005 effectively reduced inflammatory infiltrates in the lung and colon,as well as suppressed cytokine levels associated with allergic asthma compared to other strains.In addition,the supplementation of RL-H3-005 modulated the composition of gut microbiota in mice with allergic asthma.FMT results further supported the notion that modulating the gut microbiota with RL-H3-005 plays a crucial role in attenuating airway inflammatory symptoms in allergic asthma.
