摘要
恶性肿瘤的发病率和致死率均呈现出高发态势,但其有效的治疗仍然是生命医学领域面临的重大难题。蛋白材料因其特定的氨基酸序列和空间折叠结构,具有独特的生物活性、靶向性和低毒性而被大量开发作为药物递送载体用于输运药物分子,并在多种恶性肿瘤治疗中显示出优势。依据来源的不同,蛋白材料可分为天然蛋白材料和合成蛋白材料。目前,以上蛋白材料均有作为纳米药物递送载体应用的案例,并显著增强化疗、放疗、热疗及免疫治疗等对肿瘤的抑制效果,但其在肿瘤的治疗机制上不尽相同。因此,本文系统总结蛋白基纳米材料的类型及其制备工艺,阐释相关应用的抗肿瘤治疗机制,为蛋白纳米药物载体的应用和临床转化提供参考。
Malignant tumors are associated with high morbidity and mortality,yet effective treatment remains a significant challenge in the field of biomedical science.Protein-based materials have been extensively developed as drug delivery vehicles due to their specific amino acid sequences,unique three-dimensional structures,inherent biological activity,targeting capabilities,and low toxicity.These materials have demonstrated considerable promise in drug delivery systems and have shown therapeutic advantages in the treatment of various malignant tumors.Based on their origin,protein materials can be categorized into natural and synthetic types.Currently,both types have been employed as nanocarriers for drug delivery,significantly enhancing the efficacy of chemotherapy,radiotherapy,hyperthermia,and immunotherapy.However,the mechanisms by which these treatments exert anti-tumor effects vary.Therefore,this review aims to systematically summarize the types and preparation methods of protein-based nanomaterials,elucidate their anti-tumor mechanisms,and provide a reference for their application and potential clinical translation as nano-drug carriers.
作者
李飞燕
李瑶
蒋彩英
孔祥东
Li Feiyan;Li Yao;Jiang Caiying;Kong Xiangdong(Institute of Smart Biomedical Materials,School of Materials Science and Engineering,Zhejiang Sci-Tech University,Hangzhou 310018,Zhejiang,China;College of Life Sciences and Medicine,Zhejiang Sci-Tech University,Hangzhou 310018,Zhejiang,China)
出处
《中国医学前沿杂志(电子版)》
北大核心
2025年第10期30-37,I0002,共9页
Chinese Journal of the Frontiers of Medical Science(Electronic Version)
基金
国家自然科学青年科学基金项目(32301177)
2024年教育部产学合作协同育人项目(240902690024129)。
关键词
天然蛋白
合成蛋白
纳米药物
肿瘤治疗
Natural protein
Synthetic protein
Nanomedicine
Tumor therapy
