摘要
目的:探讨中国西北地区60岁以上人群晶状体厚度(lens thickness,LT)和晶状体相对位置(relative lens position,RLP)的影响因素以及与眼前房角结构的相关性,为探索晶状体在原发性闭角型青光眼疾病中的作用机制提供依据。方法:横断面研究,纳入2024年4—6月在新疆喀什地区英吉沙县社区人群中检查的60岁以上正常受检者,采用眼前节相干光断层扫描仪等,测量双眼眼球生物学参数。将患者右眼纳入研究范围,通过相关性分析和线性回归模型分析晶状体参数变化与房角结构的相关性。结果:性别、腰围和眼轴长度(axial length,AL)为RLP的独立预测因子。年龄越大,晶状体越厚,70岁前LT与AL呈正相关,眼轴、LT和RLP是眼前房角巩膜突前500μm开放距离(AOD500)的独立预测因子,其多元线性回归方程为:AOD500=-2.5014+0.0833AL-0.1157LT+7.0211RLP-0.0026Sex-0.0010身高。结论:新疆喀什地区60岁以上人群中,女性、腰围大和眼轴短提示晶状体相对位置靠前,而晶状体厚度、相对位置以及眼轴显著影响眼前房角开放距离,成为闭角型青光眼发病的潜在危险因素。
Objective:To explore the influencing factors of lens thickness(LT)and relative lens position(RLP)in individuals aged 60 and above in Northwestern China,as well as their correlation with anterior chamber angle structure.The aim is to provide evidence for exploring the role of the lens in the pathogenesis of primary angle-closure glaucoma.Methods:A cross-sectional study was conducted.Normal subjects aged 60 and above were enrolled from community-based examinations in Yingjisha County,Kashi,Xinjiang,between April and June 2024.An anterior segment optical coherence tomography was used to measure ocular biological parameters of both eyes.Only the right eyes of the subjects were included in the analysis.The correlation between changes in lens parameter and angle structure was examined through correlation analysis and linear regression models.Results:Gender,waist circumference and axial length emerged as independent predictors of the relative lens position.As age increased,the lens became thicker.Before the age of 70,lens thickness was positively correlated with axial length.Axial length,LT and RLP were identified as independent predictors of the anterior chamber angle scleral spur anterior 500-μm-opening distance(AOD500).The multiple linear regression equation is as follows:AOD500=-2.5014+0.0833AL-0.1157LT+7.0211RLP-0.0026Sex-0.0010Height.Conclusions:Among individuals aged 60 and above in Northwest China,being female,having a large waist circumference,and a short axial length are indicative of a relatively anterior lens position Furthermore,lens thickness,its relative position,and axial length significantly affect the anterior chamber angle opening distance,potentially contributing to the pathogenesis of angle-closure glaucoma.
作者
陈觉晓
陈小龙
曹子阳
朱睿辰
王颖怡
茹鑫锐
热依沙·台来提
谢玲玲
曹淑娟
李嘉永
罗雯诗
苏广兴
王珣
高新博
CHEN Juexiao;CHEN Xiaolong;CAO Ziyang;ZHU Ruichen;WANG Yingyi;RU Xinrui;TAILAITI·reyisha;XIE Lingling;CAO Shujuan;LI Jiayong;LUO Wenshi;SU Guangxing;WANG Xun;GAO Xinbo(State Key Laboratory of Ophthalmology,Zhongshan Ophthalmic Center,Sun Yat-sen University,Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science,Guangzhou 510060,China;Sun Yat-sen University,School of Medicine,Guangzhou 510080,China;Ophthalmology Medical Diagnosisi and Treatment Center,People's Hospital of Xinjiang Uygur Autonomous Region,Urumqi 830001,China;Department of Ophthalmology,the First People’s Hospital of Kashi,Kashi 844000,China)
出处
《眼科学报》
2025年第10期820-829,共10页
Eye Science
关键词
晶体参数
房角结构
眼前节相干光断层扫描
lens parameters
anterior chamber angle structure
anterior segment optical coherence tomography
