摘要
目的探索非甾体抗炎药(nonsteroidal anti-inflammatory drugs,NSAIDs)对经尿道前列腺电切术(transurethralresectionofprostate,TURP)患者下尿路症状(lower urinary tract symptoms,LUTS)改善的效果及安全性。方法回顾性分析2024年1月至2024年10月于贵州省人民医院泌尿外科行TURP手术的60例前列腺增生患者的临床资料,根据术后是否使用NSAIDs分为对照组(不使用NSAIDs)与观察组(使用NSAIDs),每组30例。收集患者年龄、前列腺特异性抗原水平、前列腺B超相关指标、手术前后国际前列腺症状评分(International Prostate Symptom Score,IPSS)、手术前后生活质量评分、最大尿流率、残余尿量、是否使用NSAIDs、NSAIDs使用时长、NSAIDs药物相关不良反应事件等临床数据,采用Logitic回归分析、多元线性回归分析等方法探究NSAIDs的使用与TURP术后LUTS改善的相关性。结果观察组术后IPSS总分(P=0.007)、IPSS储尿期症状评分(P=0.007),IPSS排尿期症状评分(P=0.068)及IPSS排尿后症状评分(P=0.016)更低;Logitic回归分析和多元线性回归分析显示移行带体积(OR=0.961,95%CI 0.925~0.998,P=0.040)、移行带指数(OR=0.002,95%CI 0.001~0.178,P=0.006)、最大尿流率(OR=1.611,95%CI1.091~2.380,P=0.017)、应用NSAIDs天数(OR=1.269,95%CI 1.006~1.601,P=0.044)为TURP术后LUTS是否改善的影响因素,多元线性回归分析中方差分析提示这些因素与TURP术后LUTS的改善具有一定的相关性(F=3.140,P=0.025)。术后随访均未见NSAIDs药物相关不良反应。结论TURP术后短期应用NSAIDs可以安全的促进患者术后LUTS的改善。
Objective To investigate the efficacy and safety of nonsteroidal anti-inflammatory drugs(NSAIDs)in improving lower urinary tract symptoms(LUTS)in patients undergoing transurethral resection of the prostate(TURP).Methods A retrospective analysis was performed on clinical data from patients with benign prostatic hyperplasia who underwent TURP.Data included age,prostate-specific antigen(PSA)levels,transrectal ultrasound parameters,International Prostate Symptom Score(IPSS)pre-and postoperatively,quality of life scores pre-and post-operatively,maximum urinary flow rate(Qmax),post-void residual urine volume(PVR),NSAID usage status,duration of NSAID administration,and NSAIDrelated adverse events.Logistic regression analysis and multiple linear regression analysis were employed to investigate the correlation between NSAID use and improvement in LUTS following TURP.Results Compared to the non-NSAID group(control group),the NSAID treated group(observation group)demonstrated significantly lower postoperative total IPSS(P=O.007),IPSS storage symptom subscore(P=0.007),and IPSS post-micturition symptom subscore(P=0.016).A trend towards lower IPSS voiding symptom subscore was observed(P=O.O68).Logistic regression analysis identified transition zone volume(OR=0.961,95%CI 0.9250.998,P=0.040),transition zone index(OR=0.002,95%CI 0.001-0.178,P=0.006),Qmax(OR=1.611,95%CI 1.091-2.380,P=0.017),and duration of NSAID administration(OR=1.269,95%CI 1.006-1.601,P=0.044)as significant factors influencing LUTS improvement after TURP.Multiple linear regression analysis(ANOVA:F=3.140,P=O.025)confirmed an association between these factors and postoperative LUTS improvement.No NSAID-related adverse events were reported during postoperative follow-up.Conclusion Short-term administration of NSAIDs following TURP safely promotes postoperative improvement in LUTS.
作者
杨慧
张珩
罗光恒
田野
安凌悦
熊敏
Yang Hui;Zhang Heng;Luo Guangheng;Tian Ye;An Lingyue;Xiong Min(Department of Urology,Guizhou Provincial People's Hospital,Guiyang,Guizhou 550002,China)
出处
《泌尿外科杂志(电子版)》
2025年第4期10-14,共5页
Journal of Urology for Clinicians(Electronic Version)
基金
贵州省基础研究(自然科学)青年引导项目(黔科合基础-[2024]青年298)
贵州省卫健委基金(gzwkj2024-027)
贵州省基础研究(自然科学)面上项目(黔科合基础MS[2025]488)。
关键词
良性前列腺增生
经尿道前列腺切除术
非甾体抗炎药
Benign prostatic hyperplasia
Transurethral resection of the prostate
Non-steroidal anti-inflammatory drugs
