摘要
传统肿瘤治疗方法面临复发率高、不良反应大和治疗靶向性不足等问题。光动力治疗(photodynamic therapy,PDT)和光热治疗(photothermal therapy,PTT)作为新兴的肿瘤局部治疗策略,以其非侵入性、高选择性和时空可控性受到广泛关注。PDT通过光敏剂在特定波长激光照射下产生活性氧物质杀伤肿瘤细胞,而PTT则通过光热剂将光能转化为热能,实现局部高温消融肿瘤组织。两种疗法均可诱导肿瘤细胞发生免疫原性细胞死亡(immunogenic cell death,ICD),激发抗肿瘤免疫反应。然而,在复杂的免疫抑制性肿瘤微环境中,这些疗法单独应用难以达到长期治疗效果。近年来,PDT/PTT与免疫治疗联合应用成为研究热点,可协同激活机体免疫系统,提高肿瘤治疗效果。本文综述PDT和PTT的抗肿瘤机制、免疫效应及其与免疫治疗的协同策略,并展望其在肿瘤治疗中的发展前景。
Traditional tumor treatments face challenges such as high recurrence rates,significant adverse reactions,and insufficient therapeutic targeting.Photodynamic therapy(PDT)and photothermal therapy(PTT),as emerging localized tumor treatment strategies,have garnered widespread attention for their non-invasive nature,high selectivity,and controllable spatiotemporal characteristics.PDT utilizes photosensitizers to generate reactive oxygen species that kill tumor cells under specific wavelength laser irradiation,while PTT employs photothermals to convert light energy into heat,achieving localized thermal ablation of tumor tissue.Both therapies can induce immunogenic cell death(ICD)in tumor cells,stimulating anti-tumor immune responses.However,within the complex immunosuppressive tumor microenvironment,these therapies alone struggle to achieve sustained therapeutic outcomes.In recent years,the combination of PDT/PTT with immunotherapy has emerged as a research hotspot,offering synergistic activation of the immune system to enhance antitumor efficacy.This review summarizes the antitumor mechanisms of PDT and PTT,their immunological effects,and synergistic strategies with immunotherapy,while exploring their developmental prospects in cancer treatment.
作者
杜洋
杨江南
符德元
Yang Du;Jiangnan Yang;Deyuan Fu(Department of General Surgery,Northern Jiangsu People’s Hospital Affiliated to Yangzhou University School of Medicine,Yangzhou 225002,China;Department of Pathology and Pathophysiology,Basic Medical College,Hunan Normal University,Changsha 410013,China)
出处
《中国肿瘤临床》
北大核心
2025年第19期1004-1012,共9页
Chinese Journal of Clinical Oncology
基金
国家自然科学基金项目(编号:82072909)资助。
关键词
光动力治疗
光热治疗
免疫治疗
肿瘤
联合治疗
photodynamic therapy(PDT)
photothermal therapy(PTT)
immunotherapy
tumor
combined therapy
