摘要
目的 探讨对慢性乙型肝炎后肝纤维化患者采用滋阴养肝汤治疗的临床效果以及安全性。方法 选取枣庄市薛城区人民医院2020年2月—2022年11月收治的90例慢性乙型肝炎后肝纤维化患者作为研究对象;以投掷硬币法作为分组依据,其中施以大黄䗪虫丸治疗的设为参照组(45例),施以滋阴养肝汤治疗的设为研究组(45例)。对比2组患者临床疗效、不良反应发生情况、肝纤维化指标。结果 研究组治疗总有效率97.78%(44/45)同参照组的82.22%(37/45)相比,显著提升(P<0.05)。研究组不良反应总发生率4.44%(2/45)同参照组的6.67%(3/45)比较,差异无统计学意义(P>0.05)。治疗前,研究组Ⅳ型胶原(Ⅳ-C)、透明质酸酶(HA)、层粘连蛋白(LN)、Ⅲ型前胶原(PCⅢ)水平同参照组比较,差异无统计学意义(P>0.05);治疗后,研究组上述指标水平同参照组比较,均明显降低(P<0.05)。结论 临床对慢性乙型肝炎后肝纤维化患者采用滋阴养肝汤治疗,效果明显,安全性良好,可有效改善肝纤维化指标。
Objective To investigate the clinical efficacy and safety of Ziyin Yanggan decoction for patients with liver fibrosis after chronic hepatitis B.Methods A total of 90 patients with liver fibrosis after chronic hepatitis B in Xuecheng District People’s Hospital from February 2020 to November 2022 were selected as the study objects.Coin-tossing method was used as the basis for grouping treatment studies.The group treated with Dahuang Zhechong pills was set as the control group(45 cases).The study group(45 cases)was treated with Ziyin Yanggan decoction.The efficacy,adverse reactions and hepatic fibrosis indexes were compared between the two groups.Results The total effective rate in the study group was 97.78%(44/45),which was significantly higher than that in the control group(82.22%,37/45)(P<0.05).The total incidence of adverse reactions in the study group was 4.44%(2/45),and there was no statis⁃tically significant difference compared with that in the control group(6.67%,3/45)(P>0.05).Before treatment,there were no statisti⁃cally significant differences in the levels of typeⅣcollagen(Ⅳ-C),hyaluronidase(HA),laminin(LN),and procollagen typeⅢ(PCⅢ)between the study group and the reference group(P>0.05).After treatment,the levels of the above indicators in the study group were significantly lower than those in the control group(P<0.05).Conclusion In clinical practice,Ziyin Yanggan decoction is used in the treatment of patients with hepatic fibrosis after chronic hepatitis B.It has a marked therapeutic effect and good safety,and can ef⁃fectively improve the indicators of hepatic fibrosis.
作者
李文臣
狄龙
LI Wenchen;DI Long(Department of Infectious Diseases,Xuecheng District People’s Hospital,Shandong Province,Zaozhuang 277700,China)
出处
《中国中医药现代远程教育》
2025年第20期165-167,共3页
Chinese Medicine Modern Distance Education of China
关键词
积聚
慢性乙型肝炎
肝纤维化
滋阴养肝汤
中医药疗法
abdominal mass
chronic hepatitis B
liver fibrosis
Ziyin Yanggan decoction
therapy of traditional Chinese medicine
