摘要
目的制备艾纳香提取物颗粒剂,并研究其抗炎镇痛活性。方法从艾纳香药材中提取艾纳香油和黄酮类成分;通过动物模型评价艾纳香提取物的抗炎镇痛活性,并采用响应面优化设计优选艾纳香颗粒剂的最佳成型工艺。结果艾纳香提取物能显著降低小鼠的扭体次数和耳廓肿胀度,对疼痛抑制率达59.32%,对肿胀抑制率达62.16%。颗粒剂的最佳成型工艺为:艾纳香提取物-乳糖(1:3.9),润湿剂为55%乙醇,黏合剂为2%羧甲基纤维素钠、添加量为5%。结论艾纳香提取物具有较好的抗炎镇痛活性;优化后的艾纳香颗粒剂成型工艺稳定可行,为艾纳香的开发与应用提供了实验依据。
OBJECTIVE To prepare the granules of Blumea balsamifera(L.)DC.extracts and to investigate its anti-inflammatory and analgesic activities.METHODS B.balsamifera oil and flavonoids were extracted from B.balsamifera,their anti-inflammatory and analgesic activities were evaluated in animal models.The granulation process of B.balsamifera granules was optimized by response surface method.RESULTS The extracts significantly reduced the number of twisting and auricular swelling in mice,and the inhibition rate of pain reached 59.32%and that of swelling reached 62.16%.The optimal granulation formulation and process were as follows;extracts-lactose=1:3.9;wetting agent was ethanol at a concentration of 55%;adhesive was sodium carboxymethyl cellulose 2%,and its addition was 5%.CONCLUSION B.balsamifera extracts have good anti-inflammatory and analgesic activities,and the optimized formulation process of B.balsamifera granules is stable and feasible,which provides the basic basis for the development and application of B.balsamifera.
作者
潘淑娟
龙利
杨会
齐维金
王鲁
PAN Shujuan;LONG Li;YANG Hui;QI Weijin;WANG Lu(School of Pharmacy,Guizhou University,Guiyang,Guizhou,550025 P.R.China;Engineering Research Center of Ministry of Education for the Development and Utilization of Southwest Characteristic Medicinal Biological Resources,Guizhou University,Guiyang,Guizhou,550025 P.R.China)
出处
《华西药学杂志》
北大核心
2025年第6期672-676,共5页
West China Journal of Pharmaceutical Sciences
基金
国家自然科学基金资助项目(批准号:32160849,31760747)。
关键词
艾纳香
艾纳香油
黄酮类物质
抗炎
镇痛
颗粒剂
响应面法
成型工艺
Blumea bulsamifera(L.)DC.
Blumea balsamifera oil
Flavonoid
Anti-inflarmmatory
Analgesic
Granules
Response surface method
Formulation process
