摘要
Objective To estimate the antiviral activities of ulvan derived from Ulva pertusa,and initiate a preliminary exploration into its mechanism for the potential utilization of ulvans in the future.Methods Employing methodologies rooted in molecular biology and virology,such as viral infection and FACS,the effect of ulvan on virus infection and the innate immune responses in cells were evaluated.Results Ulvan significantly restricted vesicular stomatitis virus(VSV)infection.Preliminary exploration on its mechanism indicated that ulvan activated the innate immune,and induced type I interferons(IFN-Ⅰ)expression to restrict viral infection.
目的评价孔石莼多糖的抗病毒活性,探索其抗病毒活性的分子机制,为石莼多糖的后续开发提供理论支撑。方法运用病毒感染、流式细胞术等分子生物学和病毒学手段,在细胞模型中评估孔石莼多糖对病毒感染抑制活性,及其对相关信号通路的影响。结果孔石莼多糖显著抑制水疱型口炎(VSV)病毒感染,作用机制研究表明孔石莼多糖可激活天然免疫,诱导I型干扰素(IFN-Ⅰ)表达,抵抗病毒感染。
出处
《中国海洋药物》
2025年第5期43-50,共8页
Chinese Journal of Marine Drugs
基金
国家自然科学基金项目(U22A20582)资助。
