摘要
目的 通过系统综述与荟萃分析评估口腔鳞状细胞癌(OSCC)患者口腔微生物群组成的改变。方法 计算机检索PubMed、Embase、Cochrane图书馆、Web of science、万方数据、中国知网数据库,搜集关于OSCC口腔微生物组的研究,检索时限均为建库至2025年3月25日。依据既定纳入与排除标准筛选文献并提取数据,采用Stata 17.0软件对纳入研究中细菌属丰度变化进行Meta分析。结果 共纳入23项研究,包含1 718例参与者。纳入研究分为病例对照研究(14篇)以及癌组织与配对癌旁组织比较研究(9篇)两类。Meta分析结果显示,在属水平上,梭杆菌属在OSCC患者[标准化均差(SMD)=0.52,95%CI:0.39~0.65,P<0.001]及癌组织(SMD=0.89,95%CI:0.55~1.24,P<0.001)中的丰度均增高;卟啉单胞菌属在OSCC患者(SMD=0.17,95%CI:0.02~0.33,P=0.030)及癌组织(SMD=0.31,95%CI:0.10~0.53,P=0.005)中的丰度亦增高;而链球菌属在OSCC患者(SMD=-0.43,95%CI:-0.85~-0.01,P=0.044)及癌组织(SMD=-0.66,95%CI:-0.96~-0.37,P<0.001)中的丰度则降低。结论 OSCC患者及其癌组织中梭杆菌属、卟啉单胞菌属丰度增高,而链球菌属丰度降低,提示口腔菌群失调可能与OSCC的发生发展相关。
Objective To assess changes in composition of oral microbiota in oral squamous cell carcinoma(OSCC)by systematic review and Meta-analysis.Methods Computer searches were conducted in databases such as PubMed,Embase,Cochrane Library,Web of Science,Wanfang Data and CNKI to gather research on the oral microbiome of OSCC.The search covered the period from the establishment of databases to March 252025.Literature was screened and data extracted according to literature inclusion and exclusion criteria,and Meta-analysis of changes in the abundance of bacterial genera in included studies was performed using Stata 17.0.Results A total of 23 studies involving 1718 participants were included.These studies were divided into two categories:(1)case-control studies(n=14)and(2)cancer tissue versus paired paracancerous tissue(n=9).At the genus level,Fusobacterium was increased in abundance in OSCC patients(SMD=0.52,95%CI:0.39-0.65,P<0.001)and cancer tissue(SMD=0.89,95%CI:0.55-1.24,P<0.001).Porphyromonas was increased abundance in OSCC patients(SMD=0.17,95%CI:0.02-0.33,P=0.030)and cancer tissue(SMD=0.31,95%CI:0.10-0.53,P=0.005).Streptococcus was decreased in OSCC(SMD=-0.43,95%CI:-0.85--0.01,P=0.044)and cancer tissue(SMD=-0.66,95%CI:-0.96--0.37,P<0.001).Conclusion Fusobacterium and Porphyromonas increase and Streptococcus decrease in OSCC patients and cancer tissue,suggesting that oral flora dysbiosis is associated with the development of OSCC.
作者
曹启轩
杨悦
沈军
CAO Qixuan;YANG Yue;SHEN Jun(Medical School of Nankai University,Tianjin 300070,China;Tianjin Stomatological Hospital;Tianjin Medical University Cancer Institute&Hospital)
出处
《天津医药》
2025年第12期1295-1303,共9页
Tianjin Medical Journal
基金
天津市医学重点学科(专科)计划项目(TJYXZDXK-009A)。
