摘要
目的探讨如意珍宝丸联合经皮穴位电刺激治疗产后腰骶疼痛患者的临床效果与安全性。方法采用单盲随机对照试验设计,选择温州市人民医院2021年9月至2023年5月收治的150例产后腰骶疼痛患者作为研究对象,依据随机数字表法将患者分为研究组与对照组,各75例。2组患者均给予常规干预,对照组再采取经皮穴位电刺激,研究组在对照组的基础上口服如意珍宝丸。比较2组的视觉模拟评分法(visual analogue scale,VAS)评分、Oswestry功能障碍指数(Oswestry disability index,ODI)评分,血清神经肽Y(neuropeptide Y,NPY)水平、P物质(substance P,SP)和前列腺素E2(prostaglandin E2,PGE2)水平,以及疗效和安全性。结果治疗1周和2周后,研究组的VAS和ODI评分以及SP和PGE2水平低于对照组,NPY水平高于对照组(P<0.05),且随着时间的推移,2组VAS和ODI评分以及SP和PGE2水平呈下降趋势,NPY水平呈上升趋势升(P<0.05)。研究组的总有效率高于对照组(P<0.05),且2组均未发生明显不良反应。结论如意珍宝丸联合经皮穴位电刺激可减轻产后腰骶疼痛患者的疼痛,其机制可能与上调NPY表达及下调SP和PGE2表达有关,且疗效显著,安全性良好。
Objective To investigate the clinical efficacy and safety of Ruyi Zhenbao Pill combined with transcutaneous electrical acupoint stimulation(TEAS)in the treatment of patients with postpartum lumbosacral pain.Methods A single-blind,randomized controlled trial was conducted.A total of 150 patients with postpartum lumbosacral pain admitted to Wenzhou People's Hospital between September 2021 and May 2023 were selected and randomly assigned,using a random number table,to either the intervention group or the control group,with 75 cases in each group.Both groups received a conventional intervention.The control group additionally received TEAS,while the intervention group received oral Ruyi Zhenbao Pill in addition to the control group's treatment.Visual analogue scale(VAS)score,Oswestry disability index(ODI)score,and serum levels of neuropeptide Y(NPY),substance P(SP),and prostaglandin E2(PGE2)were compared between the two groups,as were efficacy and safety.Results After 1 and 2 weeks of treatment,the intervention group showed lower VAS and ODI scores,and lower serum SP and PGE2 levels,but higher NPY levels compared to the control group(P<0.05).Over time,both groups showed decreasing trends in VAS and ODI scores and in serum SP and PGE2 levels,and an increasing trend in NPY levels(P<0.05).The total effective rate was higher in the intervention group than in the control group(P<0.05).No significant adverse reactions were observed in either group.Conclusion Ruyi Zhenbao Pill combined with TEAS can alleviate pain in patients with postpartum lumbosacral pain.The mechanism may be related to the upregulation of NPY expression and downregulation of SP and PGE2 expression.This combination therapy demonstrates significant efficacy and a favorable safety profile.
作者
叶亚云
金掌
王大风
许智利
邵希文
YE Yayun;JIN Zhang;WANG Dafeng;XU Zhili;SHAO Xiwen(Department of Acupuncture and Tuina,Wenzhou People's Hospital,Wenzhou 325700,China;Department of Spinal Surgery,Wenzhou People's Hospital,Wenzhou 325700,China;Department of Orthopedics,Wenzhou People's Hospital,Wenzhou 325700,China;Department of Emergency Medicine,Wenzhou People's Hospital,Wenzhou 325700,China)
出处
《药学进展》
2025年第10期914-918,共5页
Progress in Pharmaceutical Sciences
基金
浙江省医学会课题(No.2024ZYC-A74,No.2024ZYC-A75)
温州市科技局项目(No.Y20220220)。
关键词
产后腰骶疼痛
如意珍宝丸
经皮穴位电刺激
腰骶功能
疗效
postpartum lumbosacral pain
Ruyi Zhenbao Pill
transcutaneous electrical acupoint stimulation
lumbosacral function
efficacy
