摘要
目的研究前脂肪细胞因子-1(preadipocyte factor-1,Pref-1)预测早期糖尿病肾病(diabetic nephropathy,DN)的价值,并探究前列地尔和胰激肽原酶联合治疗DN的效果。方法回顾性纳入山西省运城市中心医院于2022年8月—2023年10月收治的104例2型糖尿病(type 2 diabetes mellitus,T2DM)患者,按尿蛋白排泄率(urinary albumin excretion rate,UAER)分为T2DM组和DN组。利用Pearson相关性、受试者工作特征(receiver operating characteristic,ROC)曲线分析Pref-1与肾功能的关系及预测价值,并观察前列地尔和胰激肽原酶治疗DN的效果。结果治疗前,DN组Pref-1、UAER、尿素氮(blood urea nitrogen,BUN)、血肌酐(serum creatinine,Scr)高于T2DM组,预估肾小球滤过率(estimated glomerular filtration rate,e GFR)低于T2DM组(P<0.05)。Pref-1与UAER,BUN,Scr呈正相关,与e GFR呈负相关(P<0.05)。Pref-1诊断DN的曲线下面积(area under the curve,AUC)为0.728,且大于对应的最佳界值(0.352)。DN组经治疗后的Pref-1,UAER,BUN,Scr水平低于治疗前,eGFR高于治疗前(P<0.05)。结论Pref-1在早期DN中呈现高水平表达,预测早期DN的价值较高。前列地尔和胰激肽原酶的疗效较好,可促进患者Pref-1水平降低和肾功能改善。
Objective To investigate the predictive value of preadipocyte factor-1(Pref-1)for early diabetic nephropathy(DN)and to evaluate the efficacy of the combined therapy with alprostadil and pancreatic kininogenase on DN.Methods A retrospective study was conducted on 104 patients with type 2 diabetes mellitus(T2DM)admitted to Yuncheng Central Hospital,Shanxi Province,between August 2022 and October 2023.Participants were divided into T2DM group and DN group based on their urinary albumin excretion rate(UAER).Pearson correlation and receiver operating characteristic(ROC)curve were used to analyze the relationship between Pref-1 and renal function and its predictive value.The therapeutic effects of alprostatil and pancreatic kininogenase on DN were also evaluated.Results Before treatment,the DN group had significantly higher levels of Pref-1,UAER,blood urea nitrogen(BUN),and serum creatinine(Scr),and a lower estimated glomerular filtration rate(eGFR)than the T2DM group(P<0.05).Pref-1 was positively correlated with UAER,BUN,and Scr,and negatively correlated with eGFR(P<0.05).The area under the curve(AUC)of Pref-1 for diagnosing DN was 0.728,which is greater than the corresponding optimal cut-off value(0.352).After treatment,the DN group showed significant reductions in Pref-1,UAER,BUN,and Scr levels,and an increase in eGFR compared to pre-treatment levels(P<0.05).Conclusion Pref-1 is highly expressed in early DN and demonstrates considerable value in predicting early DN.The combined therapy with alprostadil and pancreatic kininogenase is effective,facilitating the reduction of Pref-1 levels and the improvement of renal function in patients.
作者
申焕蓉
落恒
刘红艳
朱萌阳
SHEN Huanrong;LUO Heng;LIU Hongyan;ZHU Mengyang(Department of Nephrology,Yuncheng Central Hospital of Shanxi Province,Yuncheng 044000,China)
出处
《药学进展》
2025年第10期867-871,共5页
Progress in Pharmaceutical Sciences
基金
山西省运城市中心医院课题(No.YNJC2021008)。
